This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
This National Science Foundation (NSF) Project Grant award, funded under the Integrative Activities program (CFDA 47.083), supports research on the structural mechanisms of bacterial extracellular DNA-recognition. The $216,149 award to the Board of Regents of the University of Nebraska, from July 1, 2023 to June 30, 2026, aims to identify and characterize novel DNA receptor subunits incorporated into bacterial surface appendages. The project will purify soluble protein constructs, measure...
This National Science Foundation (NSF) Biological Sciences Program (CFDA 47.074) Project Grant award of $960,000 to The Ohio State University will fund a 3-year study to elucidate unique aspects of protein synthesis in the Bacteroidia, an important group of intestinal bacteria. The key objectives are to: (1) examine how the platform pocket formed by ribosomal proteins contributes to translation initiation in Flavobacterium johnsoniae, (2) determine the role of the novel ribosomal protein BL38 in...
This National Science Foundation (NSF) Project Grant, awarded under the Mathematical and Physical Sciences (CFDA 47.049) program, provides $233,333 to The Ohio State University to develop and implement multifunctional DNA-based nanoscale devices. The goal is to detect genetic activity and control gene expression, particularly related to cell state and differentiated functions. The devices will enable mechanical control of gene regulation and provide insights into how chromatin structure and...
The Ohio State University was awarded a $988,596 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074). The grant will support research from August 1, 2021 to July 31, 2025 on the structural dynamics and function of proteins using nuclear magnetic resonance spectroscopy and computational methods. The Biological Sciences program aims to advance the field and strengthen the national...
This Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $300,000 to the University of Kansas Center for Research Inc. from February 1, 2023 to January 31, 2025. The award will support research investigating delivery and trafficking of DNA introduced to cells from environmental sources using the genetically tractable organism Caenorhabditis elegans. The project aims to gain new...
Oregon State University was awarded a $711,268 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences. The grant is part of the Biological Sciences program (CFDA 47.074) and will fund research from July 1, 2021 to June 30, 2024 exploring self versus group-sensing in bacteria. As part of the Biological Sciences program's goal to strengthen the nation's biological research enterprise and increase scientific understanding, this project aims to advance...
This $573,937 five-year Project Grant was awarded on February 1, 2024 by the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The grant will fund research at the Massachusetts Institute of Technology (MIT) to understand how changes in DNA structure impact the behavior of synthetic gene circuits and gene expression more broadly. The project aims to develop a better understanding of supercoiling-mediated...
The Ohio State University was awarded a $200,000 Project Grant from the National Science Foundation's Division of Materials Research under the Mathematical and Physical Sciences program (CFDA 47.049). The award supports fundamental research to develop self-assembled materials constructed from DNA with adaptable structures, unique mechanical properties, signal processing capabilities, and the ability to form a variety of materials from a single reconfigurable building block. The research aims...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) will provide $563,387 to The University of Mississippi to investigate the function of an unknown protein that influences pilus biosynthesis in certain bacteria. The project aims to characterize how this conserved protein, BRESU_2828, interacts with other proteins to regulate pilus formation, which is critical for bacterial attachment and biofilm development. The research will utilize...