Project Grant 2341288
Award Date
4/1/24
Completion Date
3/31/28
Dollars Obligated
$150K
Funding Federal Agency
Division of Chemistry
Awarding Federal Agency
Division of Molecular and Cellular Biosciences
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Nashville, TN 37203, USA
Similar Awards
This $393,263 National Science Foundation Division of Chemistry Project Grant will support collaborative research between the University of California, Davis and the University of Utah to study DNA repair mechanisms. The research aims to apply a chemical biology approach to reveal insights into base excision repair glycosylases that identify and initiate repair of rare DNA bases with subtle damage. Specifically, the team will develop transition state mimics to test the idea that evolutionarily...
This $246,424 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to define the initiation and early steps of recombination at DNA double strand breaks in human cells. The research aims to leverage novel methods to understand how cells choose different DNA repair mechanisms, with implications for fields like gene editing, cancer treatment, and personalized medicine. Additionally, the project will provide training...
This $184,017 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) supports a collaborative research project led by Professors Pablo Sobrado of Missouri University of Science and Technology and John Tanner of the University of Missouri Columbia. The project explores the mechanisms, functional diversity, and conformational dynamics of flavin-dependent monooxygenase enzymes found in plants. The research aims to establish...
This $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the structural biology of RNA and RNA-protein interactions through May 2024. Funded under the Biological Sciences program (CFDA 47.074), this award to Vanderbilt University will utilize joint cryo neutron/x-ray crystallography techniques to better understand the importance of the 2'-hydroxyl group in RNA's expanded three-dimensional structure compared to DNA....
This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) totaling $329,172 funds a collaborative research project to investigate how the SMC5/6 protein complex manages branched DNA structures during DNA repair processes. The research teams at North Carolina State University will use complementary biochemical and high-speed atomic force microscopy (HS-AFM) methodologies to examine how SMC5/6 recognizes and processes key DNA repair...
This $461,575 Project Grant, awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), supports research into how bacterial enzymes recognize and prevent the use of toxic D-amino acids in protein synthesis. The project, led by Earlham College, a private non-profit educational institution, aims to investigate the enzyme ProXP-X, which can bind both L- and D-amino acids, and determine how it protects bacterial cells from D-amino acid toxicity. The research will...
The University of California, Davis (UC Davis) received a $389,525 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) for a 5-year research project titled "CAREER: Mechanisms and Consequences of Epigenome-Recruited DNA Repair Systems in Plants." The project aims to study newly discovered DNA repair mechanisms in plants that could help protect critical genomic regions from harmful mutations. Researchers will leverage advanced...
This $900,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research at the University of Colorado (CU) to investigate the molecular mechanisms of DNA methyltransferase 1 (DNMT1)-mediated gene silencing. The project aims to utilize structural biology, biochemistry, and cell biology methods to understand DNMT1 regulation and the mechanisms cells employ to ensure DNMT1 acts on specific DNA sequences. The research will provide...
This $159,819 federal Project Grant award, provided by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), will support research by Dr. John Chaput at the University of California, Irvine to investigate the mechanism of DNA synthesis using advanced time-resolved X-ray crystallography. The goal is to capture "snapshot" images that can be assembled into an animated model showing the precise...
This Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $300,000 to the University of Kansas Center for Research Inc. from February 1, 2023 to January 31, 2025. The award will support research investigating delivery and trafficking of DNA introduced to cells from environmental sources using the genetically tractable organism Caenorhabditis elegans. The project aims to gain new...