This $400,000 federal Project Grant award from the National Science Foundation (NSF) under the Engineering (CFDA 47.041) program supports a collaborative research project between Cornell University and Swiss partners to uncover the fundamental mechanistic principles that drive connective tissue morphogenesis and develop computational design tools to engineer architected biological tissues. The key products and services to be delivered under this 4-year award include: 1) developing...
The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $601,071 Project Grant to Texas A&M Engineering Experiment Station (Tees), a division of the Texas A&M University System, to conduct research under the NSF Engineering program (CFDA 47.041). The goal of this 3-year project is to develop a predictive mathematical model of the relationship between bone morphogenetic protein (BMP) signaling and stem cell differentiation...
This $325,044 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research to develop a new "aerodynamic fiber deposition" technology to manufacture biomimetic soft fiber-reinforced composites with spatially varying fiber arrangements. The research aims to enable the production of high-throughput, highly controlled nano/microfiber patterns that mimic the complex fiber structures found in biological tissues like skin, muscle, and...
This $297,984 federal Project Grant award, funded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), supports research to develop data-driven mechanomics approaches to uncover age-related mechanoregulation of bone-mesenchymal stem cells. The research aims to quantify the mechanical forces inside living cells and determine how changes in these forces impact the cells' production and secretion of proteins that shape their surrounding environment. This knowledge could...
This $635,000 Project Grant awarded by the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation supports research to understand how mechanical boundary conditions influence tissue assembly and repair in 3D fibrous microtissues. The research aims to advance knowledge about the mechanisms by which mechanical forces regulate new tissue formation and organization, particularly as it relates to wound healing. The project will integrate in vitro experiments and...
This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research to elucidate how the fluid-like properties of tissue extracellular matrices influence cell fate decisions in response to growth factors. The $480,237 grant, awarded to The Pennsylvania State University (Penn State) on August 1, 2024, will fund the development and characterization of viscoelastic materials to study the impact of matrix viscous dissipation on cell...
This $314,769 Project Grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) supports research that aims to advance the fundamental understanding of how cells and tissues communicate information about their mechanical environment. The award, effective from February 1, 2025 to January 31, 2030, will fund the development of new material platforms based on magnetic materials that can dynamically change local stiffness via magnetic fields. Experiments will explore how...
This $500,000 project grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation supports research titled "GOALI/COLLABORATIVE RESEARCH: INSTABILITIES AND LOCAL STRAINS IN ENGINEERED CARTILAGE SCAFFOLD" being conducted at Cornell University from January 1, 2022 to December 31, 2024. The research aims to improve understanding of instabilities and local strains in engineered cartilage scaffolds, with the goal of enabling innovation in cartilage...
This $508,785 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research at Columbia University to investigate how the chemical composition and mechanical properties of biomaterials can be optimized to improve the production and function of T cells for use in cancer immunotherapy. The project aims to gain fundamental knowledge on how nutrient transport, particularly oxygen availability, within these biomaterials affects T cell...
This $624,622 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research at the University of Vermont aimed at advancing the understanding of cartilage microstructure and its relationship to function. The funded project investigates the links between quantitative magnetic resonance imaging metrics of cartilage microstructure, experimental assessments of articular cartilage function, and computational modeling of bone shape....