This is a $1,200,000 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) to the Texas A&M Engineering Experiment Station (Tees) for the period of September 1, 2024 to August 31, 2028. The grant supports research to understand how common biological signaling pathways like the Bone Morphogenetic Protein (BMP) pathway can be both widely used and flexible to meet the needs of different tissues across the animal kingdom. The project involves...
The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $153,901 Project Grant to the Texas A&M Engineering Experiment Station (doing business as Tees) to develop an Anisotropic Human Mesenchymal Stem Cell Patch with Oriented Vasculture. This grant was awarded on January 15, 2021 under the NSF's Engineering (CFDA 47.041) program to support innovation and excellence in engineering research. Specifically, the grant aims to fund Tees'...
This $297,984 federal Project Grant award, funded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), supports research to develop data-driven mechanomics approaches to uncover age-related mechanoregulation of bone-mesenchymal stem cells. The research aims to quantify the mechanical forces inside living cells and determine how changes in these forces impact the cells' production and secretion of proteins that shape their surrounding environment. This knowledge could...
This $301,721 federal Project Grant award was provided by the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) to the Regents of the University of Michigan, doing business as the University of Michigan. The award will fund research to understand the mechanisms by which bone morphogenetic protein (BMP) signaling integrates over time to control cell fate decisions in human pluripotent stem cells. The project will combine experimental and computational...
This $476,886 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research at Boston University to develop computational models for predicting the spatiotemporal distribution of growth factors in tissue engineering scaffolds. The goal is to optimize scaffold designs to achieve optimal growth factor exposure profiles that improve tissue regeneration outcomes, particularly for cartilage repair. The research utilizes reaction-diffusion...
The Texas A&M Engineering Experiment Station (Tees) was awarded a $551,017 Project Grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation. The grant will fund research from August 1, 2021 through July 31, 2024 to examine the influence of mechanical loading on the hydrolysis of biodegradable polymer implants. This work directly supports the goals of the NSF Directorate for Engineering's Engineering program (CFDA #47.041), which aims to improve...
This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) aims to develop a biomaterial platform to investigate how the extracellular matrix (ECM) influences airway basal stem cell (BC) self-renewal and differentiation. The $349,999 award to the University of Colorado-Denver will fund an interdisciplinary research project that combines expertise in materials science, stem cell biology, and regenerative medicine. The researchers will use tunable...
The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded $393,106 to Texas A&M Engineering Experiment Station under the Engineering (47.041) federal grant program. The three-year Project Grant will support collaborative experimental and computational research to understand the biomechanics governing epithelial tissue organization and development. Specifically, Texas A&M Engineering Experiment Station will utilize high-resolution imaging and...
The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded North Carolina State University a $510,838 Project Grant under the Engineering (47.041) federal grant program. The three-year award will support the BIO-MAPS: BIOMOLECULAR-ARRAY PATTERNS FOR PRECISION DIFFERENTIATION OF INTESTINAL STEM CELLS project from July 2021 through June 2024. The project aims to develop biomolecular array techniques to precisely differentiate intestinal...
The National Science Foundation awarded $212,092 under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to the Texas A&M Engineering Experiment Station (Tees) of the Texas A&M University System for a two-year collaborative research project from December 2021 to November 2023. The project aims to advance biomaterials design through computational simulation and manipulation of intrinsically disordered proteins. Specifically, researchers will work to better...
The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $601,071 Project Grant to Texas A&M Engineering Experiment Station (Tees), a division of the Texas A&M University System, to conduct research under the NSF Engineering program (CFDA 47.041). The goal of this 3-year project is to develop a predictive mathematical model of the relationship between bone morphogenetic protein (BMP) signaling and stem cell differentiation decisions. The researchers will employ advanced microscopy techniques, genetics, and mathematical approaches to quantitatively investigate the feedback loops regulating the BMP signaling pathway in germline stem cells and differentiating cells. The resulting model is expected to advance the fundamental understanding of BMP signaling and enable more reliable external manipulation of stem cell decisions, with potential impacts on stem cell biology and human health applications. No subawards are planned under this award.