Project Grant 2342927
- The National Science Foundation (NSF) Division of Mathematical Sciences awarded a $200,000 Project Grant to the University of California, Davis (UC Davis) under the Mathematical and Physical Sciences program (CFDA 47.049). The 3-year grant, effective August 15, 2023, will fund research into the topology and infection dynamics of bacteriophage viruses. The project aims to provide a thorough characterization of DNA organization inside phage capsids and its delivery during infection, bridging...
- The Regents of the University of Minnesota, through the Office of Sponsored Projects Administration, has received a $200,000 Project Grant award from the National Science Foundation's (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049). The award, effective August 15, 2023 through July 31, 2026, will support collaborative research to characterize the topology and infection dynamics of bacteriophage viruses. Key focus areas include...
- This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) Federal Grant Program provides $987,566 to the University of California, Los Angeles (UCLA) to conduct research on viral self-assembly, from test tube to cell cytoplasm. The award period runs from December 15, 2024 to November 30, 2028. The key objectives of this project are to elucidate the differences between in vitro and in cellulo viral processes by progressively adding molecules...
- The National Science Foundation (NSF) awarded a $445,153 Project Grant to the San Diego State University Research Foundation under the Biological Sciences (CFDA 47.074) federal grant program. The grant supports research to investigate how RNA genomes of bacteriophages (viruses that infect bacteria) are packaged into their protective protein capsids. Specifically, the project will describe the RNA structures involved in selective packaging and identify key signals recognized by the coat...
- This Project Grant award of $659,949.00 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), to the University of Connecticut (UConn) on April 15, 2025. The award supports fundamental research to achieve a mechanistic understanding of the protein-protein interactions involved in the assembly of viral capsids, with a focus on the bacteriophage P22 model system. Key research goals include: 1)...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $273,652 to Phage Refinery LLC aims to develop a rapid and efficient parametric model for predicting the likelihood that a given bacteriophage (phage) will survive sufficiently long in the presence of an active immune system to be effective as a treatment against their target bacterial infection. The project will gather physical parameters and in-vivo persistence data for 400...
- This federal Project Grant award of $377,500.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to explore the mechanisms by which bacteriophages (viruses that infect bacteria) interact with bacterial glycoconjugates (carbohydrate-containing molecules). The project aims to investigate the strategies used by certain phages to replace canonical DNA bases with non-canonical bases, as well...
- This $400,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research to model the complex dynamics of viruses and bacteria in ancient ocean-like environments. The project aims to identify "keystone" viruses that significantly influence microbial community structure and biogeochemistry in these stable, oxygen-free lake ecosystems. The research will develop innovative mathematical methods to predict...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded a $479,999 Project Grant to The Johns Hopkins University to explore the interactions between CRISPR-Cas systems and temperate bacteriophages. The 5-year research project, starting on March 1, 2025, aims to investigate how CRISPR-Cas systems, which protect bacteria from viral infections, can exploit the life cycle of temperate phages to acquire new memories. The findings are expected to inform...
- This National Science Foundation Project Grant of $880,632 supports research into drivers and effects of latent phage activation in marine SAR11 bacteria. Funded under the Geosciences program (CFDA 47.050), this three-year award to the University of California, Los Angeles will fill critical knowledge gaps about host-virus interactions in the global oceans. Through field surveys, laboratory experiments, and mathematical modeling, the grantee will quantify the frequency of prophage infections...
The National Science Foundation (NSF) awarded a $802,161 Project Grant to the University of Massachusetts Medical School (UMass Medical) to study the structural mechanisms of bacteriophage (phage) infection and assembly. This 3-year grant, effective June 1, 2024, aims to advance the understanding of virus-host interactions, promote the development of effective antiviral strategies, and leverage phage-related applications. The research will focus on three aspects of the phage life cycle: virus assembly, cellular attachment, and infection. Specifically, the project will elucidate how phage capsids assemble, investigate the mechanism of tail tube polymerization, and determine the phage components involved in bacterial host recognition. Additionally, the project seeks to establish how phage genomes cross the bacterial periplasm, investigate the formation of intracellular phage vesicles, and elucidate phage assembly mechanisms inside bacterial cells. The results of this work are expected to inform the engineering of viral components for novel nanomaterial development and reveal how phages evade bacterial defense systems.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $802.2k | 5/30/24 |