This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Brainstorm Therapeutics, Inc. aims to develop and validate a novel Parkinson's disease drug discovery platform using patient-derived midbrain organoids. The platform will guide therapeutic candidate identification, patient selection, and trial endpoint refinement to accelerate the development of effective disease-modifying Parkinson's treatments. Key innovations...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to establish the role of alpha-synuclein-mediated membrane permeabilization in the spread of alpha-synuclein aggregates related to Parkinson's disease and related dementias. The $406,260 award to Purdue University will leverage fluorescence lifetime imaging microscopy...
This federal Project Grant award, funded by the National Science Foundation (NSF) Engineering program (CFDA 47.041), will support research to investigate how changes in brain function due to Parkinson's disease (PD) impact movement dysfunction. The $199,401 award to Florida Polytechnic University, a state-controlled institution of higher learning, will employ modeling, simulation, and robotic-based movement studies to gain insights into the neural mechanisms underlying both inhibitory and...
This National Science Foundation (NSF) Project Grant, awarded under the Engineering program (CFDA 47.041), provides $357,033 to North Dakota State University (NDSU) from August 15, 2023 to July 31, 2026 to support research on protein manipulation and engineering using an electronic biochemical approach. The project aims to develop a single-molecule manipulation technique to study the dynamics of protein-protein interactions, which is critical for understanding the causes of diseases related to...
This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $154,000 in funding to Boston University from July 1, 2024 to June 30, 2027 to conduct research on protein aggregation and liquid-liquid phase separation (LLPS). The project, a collaborative effort between US and French researchers, aims to elucidate how protein-rich droplets can promote the pathological aggregation of proteins associated with neurodegenerative diseases,...
This $518,693 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will fund research to develop an integrated framework for recording and decoding multimodal neural associations of visual hallucinations and motor functions in Parkinson's disease (PD). The research team, which includes experts in neural signal processing, neurology, and deep learning, will leverage electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS)...
The National Science Foundation (NSF) awarded a $253,890 Project Grant under the Biological Sciences program (CFDA 47.074) to Western University of Health Sciences to conduct research on sensory membrane proteins. The goal is to develop computational tools capable of realistic simulations of how these proteins respond to external stimuli like pressure, heat, and sound. The research project, titled "Collaborative Research: Ultra-Fast Simulations of Sensory Membrane Proteins with Validation...
The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $135,000 Project Grant to the University of Central Florida (UCF) for the project "COLLABORATIVE RESEARCH: EAGER: 3D BIOPRINTED ORGANOIDS FOR STUDYING THE MECHANISM OF CEREBROVASCULAR AGING". This award supports the development of 3D bioprinted cerebrovascular organoids derived from human induced pluripotent stem cells to study the impact of cellular senescence...
This $1,585,446 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop a "nano scavenger" diagnostic and therapeutic agent for Parkinson's disease (PD). The research, conducted by Baylor College of Medicine, aims to validate the preclinical potential of a liposome-based agent that binds to oligomeric alpha-synuclein in...
This three-year, $240,006 project grant from the National Science Foundation's Engineering program (CFDA 47.041) funds research at Veterans Education & Research Association of Northern New England Inc. in White River Junction, VT to develop a multiplexed microbiosensing platform for understanding real-time neurotransmitter dynamics in the brain. The Engineering program aims to foster innovation and excellence in engineering research, and this project will work to improve understanding of...