This Project Grant award from the National Science Foundation Division of Integrative Organismal Systems (CFDA 47.074 - Biological Sciences) provides $899,975 to Baylor College of Medicine to investigate the development and synchronization of the social soil amoeba Dictyostelium discoideum. The research aims to gain insights into the organization and coordination of multicellular organisms. Advanced techniques such as single-cell RNA sequencing and RNA sequencing will be used to quantify...
This National Science Foundation project grant of $1,261,723 will fund research into the predatory behavior of the amoeba Dictyostelium discoideum through January 2027. Under the Biological Sciences program (CFDA 47.074), the award made to Washington University will support investigation into how this microbe evolves to be a generalist or specialist predator of bacteria. The researchers will study D. discoideum's responses to a panel of 15 diverse bacterial species through experiments on...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $139,341 project grant to the Regents of the University of California, San Francisco (UCSF) under the NSF Biological Sciences program (CFDA 47.074). The 3-year grant, effective August 1, 2023, supports collaborative research to investigate the biomechanical mechanisms underlying wound resilience in the single-celled organism Stentor coeruleus. The research will leverage cell biology, microfluidics, and...
This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $293,514 Project Grant to The Trustees of Trinity College in Hartford, Connecticut. The grant supports research from September 1, 2021 to August 31, 2024 under the Biological Sciences program (CFDA 47.074). The grant funds development of microelectrophoretic and statistical tools to study kinase- and reactive oxygen species-based signaling pathways in the social amoeba Dictyostelium discoideum. The...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $629,896 Project Grant to the University of Wisconsin-Madison on February 15, 2021 with a completion date of January 31, 2026. The grant supports research under the Biological Sciences program (CFDA 47.074) to advance understanding of heterogeneous decision-making in individual microbes and populations through synthetic approaches. As the official program description indicates, the Biological Sciences...
This $1,201,221 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), will fund research into the impact of charge regulation on conformational and phase equilibria of intrinsically disordered proteins. The awardee, Washington University in University City, Missouri, will leverage new computational and experimental methods to study how specific proteins known as intrinsically disordered proteins...
The National Science Foundation awarded a $367,636 Project Grant to the Massachusetts Institute of Technology from March 1, 2021 through February 29, 2024 under the Biological Sciences program (CFDA 47.074). The grant funds collaborative research on multidimensional single-cell phenotyping to elucidate relationships between genomes and phenotypes. The Biological Sciences program aims to advance biological knowledge and understanding of major problems through basic research. This award supports...
This $133,324 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program supports research on the evolution of multicellular organisms from single-celled ancestors. The project, titled "STAR: Kin Recognition and the Transition to Aggregative Multicellularity," will use the yeast Saccharomyces cerevisiae as a model system to investigate whether the ability to recognize and preferentially bind to genetically related cells (kin...
This National Science Foundation project grant award of $138,000 provides funding from November 1, 2022 through October 31, 2024 to support research and training under the Biological Sciences federal grant program (CFDA 47.074). The award will fund a postdoctoral fellowship to investigate how gene-environment interactions have shaped the repeated evolution of differentiated multicellularity. The fellow will employ single-cell transcriptomics and comparative analyses to examine how...