Project Grant 2326142
- The University of Houston was awarded a $500,000 Project Grant from the National Science Foundation to characterize persister cell metabolism in bacteria from June 2021 through May 2026. The grant was awarded under the NSF's Engineering program (CFDA 47.041) to support research characterizing the metabolism of bacterial cells that enter a dormant, non-growing state known as persistence. Persister cells play an important role in antibiotic resistance and the ability of bacteria to survive stress....
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) provides $288,428 in funding to The Washington University to conduct collaborative fundamental research on developing a new type of antimicrobial nanoparticle to combat antibiotic-resistant bacteria. The project aims to elucidate how the non-uniform surface chemistry of these specialized nanoparticles interacts with bacterial cell walls to achieve novel antimicrobial mechanisms that are less...
- This $160,000 federal Project Grant award, funded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research on the spatiotemporal dynamics of intercellular signaling in growing bacterial populations. The research aims to develop mathematical modeling techniques to better understand and predict the behavior of engineered multicellular bacterial systems, which have potential applications in areas like gut microbiome...
- This $300,000 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports a collaborative research project focused on understanding the mechanics and morphogenesis of bacterial biofilms. The award, with an effective date of December 1, 2025 and a completion date of November 30, 2028, will enable researchers at Yale University to conduct detailed observations and theoretical modeling of biofilm growth under varying environmental conditions, such as...
- The National Science Foundation awarded a $548,102 project grant under the Engineering (47.041) program to the University of Texas at Austin to develop a predictive framework for understanding how bacteria sense and respond to surface mechanics upon attachment. The three-year award beginning April 1, 2022 will support research using atomic force microscopy, high-throughput culturing, finite element modeling, quantitative confocal microscopy, and genetic manipulation to characterize the stresses,...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded a $550,000 project grant to the University of California, Berkeley to develop a miniaturized, sensitive, and user-friendly biosensing platform for rapid bacterial infection diagnostics. The award, effective April 1, 2025 through March 31, 2030, aims to create an integrated circuit (IC) chip and microfluidic system that combines physics-based dielectric spectroscopy and biochemistry-based magnetic nanoparticle...
- This $300,000 project grant, awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041), is focused on collaborative research to deepen the understanding of biofilm development and growth in constrained environments. The project aims to leverage highly tunable bacterial biofilm systems as a model to study the mechanics and morphogenesis of biological growth processes. Through a combination of confocal imaging, data analysis, and theoretical modeling, the...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant awarded to Baylor College of Medicine seeks to uncover the specific genes that confer antibiotic resistance in E. coli through a novel approach inspired by statistical physics. The $1,534,925 award spanning Aug 2024 to Jul 2027 will grow E. coli cultures and analyze the mutational ensemble using thermodynamic principles to predict the genes underlying antibiotic resistance. This technique aims to bridge...
- The National Science Foundation (NSF) awarded a $949,997 Project Grant to Iowa State University of Science and Technology under the Biological Sciences program (CFDA 47.074) to investigate the role of environmental factors in the development of antimicrobial resistance (AMR) in municipal wastewater treatment plants. The five-year research project, starting November 1, 2023, will conduct field, laboratory, and computational studies to determine how susceptible bacterial strains are replaced by...
- This $100,000 Project Grant award from the National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research to develop new theory and predictive models for understanding how environmental pressures shape the evolution of virulence in opportunistic bacterial pathogens. The project aims to: (I) Develop and test predictive models of strain-specific virulence, transmission, and environmental origins for the model pathogen Pseudomonas aeruginosa; and (II)...
The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $441,868 Project Grant to the University of Houston System (UH) to investigate bacterial persistence and antibiotic tolerance, a critical global public health challenge. The primary research objectives are to: (1) utilize high-throughput screening and genomic sequencing to identify genes important for bacterial persistence, (2) validate potential persistence-mediating mechanisms, and (3) conduct genetic studies on candidate persistence genes with therapeutic potential. The project will also provide learning opportunities for 4th-8th grade students and research experiences for undergraduate and graduate students. No subwards are planned under this grant, which has an award date of April 1, 2024 and an ultimate completion date of March 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $441.9k | 5/8/24 |