This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $526,873 to the Regents of the University of California at Riverside to computationally investigate the mechanisms of "molecular glues" that mediate protein-protein associations and the effects of protein co-localization on enhancing overall protein function. The overarching goals are to computationally guide the design of molecular glues and protein...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $448,150 in funding to the University of Massachusetts (UMass) to develop a general approach for rapidly modulating specific protein-protein interactions (PPIs) on living cell membranes. The key objectives are to establish a modular antibody- and aptamer-directed proximity labeling method for targeted DNA barcoding of cell membrane proteins, particularly human receptor...
This $1,042,995 National Science Foundation project grant, awarded on March 15, 2023 under the Biological Sciences (47.074) program, funds research at Oregon State University and Mount Holyoke College to discover novel functional RNA classes through computational integration of massively parallel RNA-binding protein binding and structure data. The grantees will develop new experimental and computational methods to systematically identify unknown non-coding RNA classes by combining known and...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences and Division of Mathematical Sciences awarded a $550,000 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of Texas at Austin. The grant, titled "COLLABORATIVE RESEARCH: MODULUS: PROTEIN DROPLETS DRIVE MEMBRANE BENDING AND CYTOSKELETAL ORGANIZATION," seeks to improve understanding of how protein droplets interact with cellular membranes and the cytoskeleton. The...
This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $206,912 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of North Carolina at Chapel Hill. The three-year grant, effective August 1, 2023 through July 31, 2026, supports collaborative research to enhance the understanding of protein structures and behaviors at extreme temperature and pressure conditions. The research aims to develop rules for predicting protein...
The National Science Foundation (NSF) awarded a $253,890 Project Grant under the Biological Sciences program (CFDA 47.074) to Western University of Health Sciences to conduct research on sensory membrane proteins. The goal is to develop computational tools capable of realistic simulations of how these proteins respond to external stimuli like pressure, heat, and sound. The research project, titled "Collaborative Research: Ultra-Fast Simulations of Sensory Membrane Proteins with Validation...
This $946,895 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research to advance the understanding of protein phosphorylation and its role in cell division. The project will utilize computational, biochemical, proteomic, and cell biology approaches to identify new kinase enzymes and their substrate proteins involved in regulating the fidelity of cell division processes. The research aims to elucidate the...
This National Science Foundation (NSF) CAREER award (CFDA 47.074 Biological Sciences) provides $125,896 in funding to Western Washington University from February 1, 2025 to January 31, 2030. The project aims to understand the biophysical principles that govern the conformational behavior and self-assembly of intrinsically disordered proteins (IDPs). Using advanced computational methods including molecular dynamics simulations, enhanced sampling techniques, and machine learning, the research will...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $221,474 Project Grant to the University of Vermont & State Agricultural College (UVM) for the period of August 1, 2023 to July 31, 2026 under the Biological Sciences program (CFDA 47.074). The primary objective of this grant is to enable the principal investigator to acquire expertise in utilizing single-particle cryo-electron microscopy (cryo-EM) techniques to elucidate the molecular structures...