Project Grant 2322963
- This Project Grant award for $344,139 from the National Science Foundation (NSF) Division of Materials Research under the Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research to develop and study polymer nanoparticles (polymersomes) with the dual capability of delivering therapeutics and enabling ultrasound imaging. The research team from George Washington University aims to synthesize nanoscale polymeric particles that can evade the body's defense system,...
- This collaborative research project grant of $279,964, awarded September 1, 2026, by the National Science Foundation's Division of Civil, Mechanical, and Manufacturing Innovation (CFDA 47.041—Engineering) supports fundamental research at the University of Delaware through August 31, 2029. The project delivers predictive computational modeling and experimental research to advance understanding of how mechanical properties of soft nanoparticles interact with cellular membrane mechanics to...
- This National Science Foundation (NSF) Engineering Program project grant awarded to the Massachusetts Institute of Technology (MIT) provides $429,384 in funding to study how drug nanoparticles adhered to leukocyte (white blood cell) surfaces influence their mechanical properties and movement through microscale blood vessel networks. The 5-year research effort, from March 2024 to February 2029, will use a combination of biophysical models and microfluidic experiments to generate fundamental...
- This Project Grant award of $365,502 from the National Science Foundation (NSF) Engineering program (CFDA 47.041) is funding collaborative research at The Pennsylvania State University to improve the spatiotemporal temperature control of solvated gold nanoparticles. The goal is to broaden the understanding of heat transfer across solid-liquid interfaces, which is critical for advancing therapeutic approaches using light-activated gold nanoparticles for cancer treatment and drug/gene delivery....
- This five-year CAREER award of $373,802, issued May 1, 2026, by the National Science Foundation's Division of Materials Research under the Mathematical and Physical Sciences program (CFDA 47.049), funds fundamental research to advance rational design of polymeric micelle drug carriers through artificial intelligence and machine learning. The project delivers computational and experimental research outputs that decode polymer-drug molecular interactions—including π-π stacking and hydrogen...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $265,026 to Lafayette College to conduct research on the "Role of Crystallinity and Morphology in Degradation and Drug Release of PEO-b-PCL Films." The key objectives are to understand how the physical structure of the polymer material, including crystallinity and phase separation, impacts the controlled release of drug additives and the overall...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Oregon Health & Science University a Project Grant of $640,113 on June 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop multifunctional ultrasound-responsive nanoparticles (URNs) for enhanced melanoma immunotherapy. The grant supports a five-year research initiative (completion date May 31, 2031) aimed at addressing the approximately 50% of melanoma patients who do not...
- This $471,407 National Science Foundation project grant will fund research at the University of Massachusetts Amherst to develop functionalized nanoparticles that phase separate on liquid droplet interfaces, enabling control over three-dimensional droplet arrangements and the formation of macroscopic structures with unique properties. Specifically, the researchers will synthesize ligand-functionalized nanoparticles for generating nanoparticle surfactant assemblies and characterize the...
- This $475,670 CAREER Project Grant awarded by the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041) aims to develop a new method for tracking molecular changes in live tissue over time. The project will focus on creating a nanostructure-based system to continuously monitor cellular activity and interactions, which can help improve understanding of cellular behavior and advance medical treatments, particularly for complex...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $300,000 to New York University (NYU) to enhance the design of fluorinated protein fibers and hydrogels for medical applications. The key objectives are: 1) generating coiled-coil fluorinated fibers for controlled drug delivery, 2) developing fluorinated coiled-coil hydrogels that change with temperature, and 3) assessing the potential of these materials as...
COLLABORATIVE RESEARCH: DESIGN AND MECHANISTIC STUDIES ON MICROENVIRONMENT-SENSITIVE POLYMERIC NANOPARTICLES FOR SIMULTANEOUS CONTENTS RELEASE AND ULTRASOUND IMAGING -NON-TECHNICAL DESCRIPTION: MANY DISEASES, SUCH AS CANCER, ARE DREADFUL BECAUSE OFTEN, THEY ARE DIAGNOSED LATE WHEN THERAPY PROVES INEFFECTIVE. MOREOVER, WHEN THERAPY IS AVAILABLE, IT INVOLVES DEBILITATING SIDE EFFECTS, INCLUDING OTHER LIFE-THREATENING CONDITIONS. THE PRIMARY HEALTHCARE OBJECTIVES, THEREFORE, ARE EARLY, NONINVASIVE ACCURATE DIAGNOSIS AND EFFECTIVE THERAPEUTIC INTERVENTION WITHOUT HARMFUL SIDE EFFECTS. HERE A CROSS-DISCIPLINARY SCIENTIFIC TEAM LED BY A PHARMACEUTICAL CHEMIST AND AN ENGINEER FROM TWO UNIVERSITIES WILL DEVELOP AND STUDY THE FUNDAMENTAL SCIENCE BEHIND A SINGLE CLINICAL IMPLEMENT WITH THE DUAL AIM OF IMPROVED DIAGNOSTIC ULTRASOUND IMAGING AND TARGETED THERAPY WHICH BECOMES ACTIVE ONLY IN THE TARGET REGION. THE TEAM AIMS AT SYNTHESIZING NANOMETER-SIZE POLYMERIC PARTICLES. THEY ARE SIMILAR IN STRUCTURE TO BODY CELLS AND CAN CARRY THERAPEUTICS TO TARGET AREAS EVADING THE BODY?S DEFENSE SYSTEM. THE PARTICLES ARE CHEMICALLY ENGINEERED TO IMPLODE IN A SPECIFIC CHEMICAL ENVIRONMENT FOUND ONLY IN DISEASED CONDITIONS AND DELIVER THEIR CARGO. THE PROPOSED RESEARCH WILL SYSTEMATICALLY INVESTIGATE THE CHEMISTRY OF THESE NANOPARTICLES THROUGH EXPERIMENTS AND THEORY TO OPTIMIZE THEIR DESIRED EFFECTS AND THE MECHANISM BEHIND THEIR ULTRASOUND REFLECTIVITY. THE PRINCIPAL INVESTIGATORS HAVE PROPOSED AN ARRAY OF EDUCATIONAL ACTIVITIES INVOLVING HIGH SCHOOL INTERNS, UNDERGRADUATES, AND PH.D. STUDENTS IN MULTI-DISCIPLINARY PROJECTS WITH REAL-LIFE CLINICAL APPLICATIONS PREPARING THEM TO ENTER THE TWENTY-FIRST-CENTURY WORKFORCE. TECHNICAL DESCRIPTION: THE OBJECTIVE OF THIS PROPOSAL IS TO CONDUCT FOUNDATIONAL STUDIES ON POLYMER NANOPARTICLES (POLYMERSOMES) THAT ARE PROGRAMMED TO RELEASE THEIR ENCAPSULATED CONTENTS UNDER SPECIFIC BIOCHEMICAL ENVIRONMENTS COMMON IN DISEASES AND SIMULTANEOUSLY ARE RESPONSIVE TO ULTRASOUND TO ALLOW IMAGING AND ULTRASOUND-ASSISTED RELEASE. IT USES REDUCED OXYGEN PARTIAL PRESSURE AS A MODEL TRIGGER FOR RELEASE. THE PROPOSED STUDIES WILL DEVELOP THE DESIGN PRINCIPLES OF MULTIMODAL POLYMER NANOPARTICLES FOR FUTURE APPLICATIONS IN DRUG DELIVERY TO TUMORS AND SIMULTANEOUS ULTRASOUND IMAGING. THE TEAM WILL OPTIMIZE POLYMER DESIGN SO THAT THE RESULTANT POLYMERSOMES BECOME RESPONSIVE TO THE REDUCED OXYGEN LEVELS AND RELEASE THE ENCAPSULATED CONTENTS. THE NANOPARTICLES WILL BE MADE TO ENTRAP AIR ALLOWING SIMULTANEOUS ULTRASOUND IMAGING BEFORE THEIR DESTRUCTION. THESE ECHOGENIC CONTENT-BEARING POLYMERSOMES WILL BE TESTED IN THREE-DIMENSIONAL (3D) CULTURES OF CANCER CELLS CONTAINING HYPOXIC NICHES. THE AWARD WILL SUPPORT ACTIVITIES THAT BROADEN PARTICIPATION OF UNDERREPRESENTED MINORITIES IN RESEARCH AND EDUCATION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | ($273k) | 5/21/25 | ||
| Not listed | $298.3k | 7/14/23 |