Project Grant R01CA311580
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $2.27 million Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective September 23, 2025, with an anticipated completion date of August 31, 2029. This research initiative investigates the role of androgen receptor (AR) signaling in conventional dendritic cells (CDCs) and its impact on anti-tumor immune function, with particular focus on sex-based...
- Federal Grant Award Summary Oregon Health & Science University received a $662,913 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), effective August 1, 2025, through July 31, 2029. The research focuses on developing a peptide amphiphile (PA)-based universal drug delivery platform designed to address significant limitations of...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $521,002 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) on March 26, 2026, with an ultimate completion date of February 28, 2031. The award supports the development and utilization of a microphysiological bone metastasis-on-a-chip platform designed to advance understanding of prostate cancer metastasis to bone, which occurs in over 80% of advanced...
- Federal Project Grant Award Summary Oregon Health & Science University received a $2.49 million Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) on August 15, 2025, with a completion date of July 31, 2029. The award supports development and validation of fluorescence-guided surgery (FGS) technology to enable real-time nerve visualization during colorectal cancer surgical procedures. The project addresses a...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Illinois a $386,279 Project Grant on July 10, 2025, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop innovative immunotherapy screening capabilities. The grant funds the creation of a microfluidic device cassette and associated functional immune assay protocols designed to enable personalized immunotherapy screening directly on core needle biopsies from cancer patients. This...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $615,399 Project Grant to the University of California, Davis under the Cancer Treatment Research program (CFDA 93.395) for the period August 1, 2025, through July 31, 2030. The award supports the development of a transformable nanoparticle (TNP) platform designed to deliver therapeutic peptides and proteins directly to tumor microenvironments on-demand. The TNP technology transforms from nanoparticles to nanofibrils...
- Federal Project Grant Award Summary Oregon Health & Science University (OHSU) received a $356,850 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), awarded April 1, 2026, with a completion date of March 31, 2031. The research initiative, titled "Targeting YB-1 to Overcome Chemoresistance in Ovarian Cancer," focuses on developing a novel therapeutic approach to address treatment resistance in recurrent ovarian cancer...
- Federal Grant Award Summary Providence Health & Services - Oregon received a $715,710 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded May 1, 2026, with completion targeted for April 30, 2031. The research project, titled "Spatiotemporal Molecular Elucidation of Radiation-Induced Tumor Microenvironment Remodeling to Enhance Immunotherapy in Head and Neck Cancer," delivers advanced oncology research services focused...
- Federal Project Grant Award Summary The National Cancer Institute awarded the University of Southern California a $3,036,844 Project Grant on August 11, 2025, under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) to develop and validate a wireless thermos-activator device for controllable solid tumor immunotherapy. The project addresses critical limitations in Chimeric Antigen Receptor (CAR) T cell therapy by creating a portable, patient-friendly alternative to MRI-guided...
- Federal Grant Award Summary The National Cancer Institute awarded $138,846 to the University Health Network under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for a two-year Project Grant commencing August 1, 2025 and concluding July 31, 2027. The award supports the development of laboratory-generated "wild-like" mouse models designed to enhance the translational relevance of preclinical cancer and immunotherapy research. The primary deliverable involves adapting...
Oregon Health & Science University received a $640,113 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) effective June 1, 2026, through May 31, 2031. The award funds research and development of multifunctional ultrasound-responsive nanoparticles (URNs) designed to enhance immunotherapy outcomes for melanoma patients. The nanoparticles consist of hydrophobically modified silica cores with peptide amphiphile stabilizing shells that enable mechanical tumor ablation and sustained drug delivery when activated by focused ultrasound. The research integrates toll-like receptor 7/8 agonist delivery with tumor antigen and danger-associated molecular pattern release to generate pro-inflammatory, anti-cancer immune responses and overcome immunosuppressive tumor microenvironments that limit the effectiveness of conventional immune checkpoint inhibitor therapies. The project addresses a critical clinical gap in which approximately 50% of advanced melanoma patients do not respond adequately to current immunotherapies due to "cold" tumor microenvironments characterized by enriched immunosuppressive cells and cytokines. By combining mechanical tumor disruption with sustained immunostimulatory agent delivery through the multifunctional nanoparticle platform, the research aims to synergistically activate both innate and adaptive immune responses to achieve improved treatment durability and therapeutic outcomes.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $640.1k | 6/1/26 |