Project Grant 2321976
- The National Science Foundation (NSF) awarded a $339,471 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to Ferris State University to support research on the chemoenzymatic fluorination of aromatic compounds. The project, led by Dr. S. Eric Nybo, aims to develop new enzymatic tools for incorporating fluorine atoms into natural products. The research will involve undergraduate students in studying the biosynthesis of organofluorine molecules, training them in NMR...
- This $234,063 National Science Foundation (NSF) project grant, awarded under the NSF Engineering program (CFDA 47.041), seeks to engineer plants to produce enhanced therapeutic proteins and improve protein production performance. The key objectives are to: 1) investigate the glycosylation and functions of glycosyl-phosphatidyl-inositol (GPI)-anchored proteins (GPI-APs) engineered in plant cells; 2) assess the broader applicability and potential applications of GPI-APs in plant cells; and 3)...
- This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $429,656.00 to Cornell University to conduct research using synthetic biology methods to engineer microorganisms to produce valuable plant natural products. The key objectives are to reconstitute plant biosynthetic machinery in yeast in order to better understand and harness plant enzyme complexes for natural product synthesis. This research aims to develop a more resilient...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $400,000 Project Grant under the Biological Sciences program (CFDA 47.074) to The Research Foundation for The State University of New York (SUNY) to study how natural product biosynthesis interconnects with the global metabolic network, using cardiac glycoside biosynthesis in the foxglove plant as an example. The project aims to elucidate the metabolic pathways underlying cardiac glycoside...
- This federal Project Grant award of $448,286.00 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Williams College to understand how plants produce, recognize, and interact with anthranilates - a group of under-investigated secondary metabolites that have been shown to deter herbivores and decrease microbial infections in plants. The research aims to advance the understanding of plant defense mechanisms against herbivores and pathogens,...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $575,765 to Northeastern University to conduct research focused on "metabolic 'doping' to enhance production of biochemicals from sustainable C1 feedstocks." The key objectives are to understand the regulation of carbon metabolism in acetogens, bacteria that can grow on single-carbon (C1) molecules, and to genetically engineer these organisms to become more effective producers...
- This $597,945 federal Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports research by Tobias W. Giessen at the University of Michigan, Ann Arbor to investigate the structure and function of peptide-modifying enzyme filaments found in bacteria and archaea. The proposed work will generate new insights into the self-assembly and catalytic activity of these filamentous enzymes, which...
- This $1,920,000 federal Project Grant award, funded by the National Institute of Standards and Technology (NIST) under the Congressionally-Identified Projects program (CFDA 11.617), supports Ferris State University in Big Rapids, Michigan. The primary objectives are to purchase and integrate critical equipment, including a 500 MHz NMR spectrometer, generator(s), benchtop LCMS, flow cytometer, and other laboratory instruments. Additionally, the university will hire a lab technician to develop...
- This $240,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund a postdoctoral research fellowship focused on discovering and functionally exploring nature's repurposed enzymes in specialized metabolism. The research aims to identify and characterize new enzymes that have gained novel functions through evolutionary changes, with the potential to discover useful tools for biotechnology and medicine. The fellowship will support a...
- This $999,470 federal Project Grant award from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) will support a collaborative research effort to develop methods for discovering and designing small molecules that can combat antibiotic resistance, biofilms, and aflatoxin contamination. The lead institution, South Dakota State University (SDSU), will partner with South Dakota Mines (SDM) and the University of Nevada, Las Vegas (UNLV) to leverage artificial...
This $369,651 project grant awarded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research at Ferris State University to characterize the biosynthesis of glycosylated anthracyclines, a class of polyketide natural products with potential anti-cancer and antibiotic properties. The project aims to refactor two higher anthracycline pathways in actinomycetes and use combinatorial biosynthesis to synthesize new anthracycline analogs with potentially novel bioactivities. Undergraduate students will be involved in the research, which is expected to train them for careers in the biomanufacturing economy. The results will be communicated with the public through podcasts. No subawards are planned under this grant, which has a performance period from March 1, 2024 to February 28, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $369.7k | 3/6/24 |