Project Grant 2521343
- This Project Grant award from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) will provide $2,190,786 to South Dakota State University (SDSU) to develop methods for discovering and designing small molecules to combat antibiotic resistance, microbial biofilms, and aflatoxin contamination. The 4-year project will leverage artificial intelligence (AI) and machine learning (ML) tools to accelerate the identification of bioactive compounds across three focus...
- This $809,743 Project Grant award from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) will develop an artificial intelligence (AI) and machine learning (ML)-driven platform to accelerate the discovery and optimization of small molecules for combating antibiotic resistance, biofilms, and aflatoxin contamination. The collaborative effort between South Dakota State University (lead), South Dakota Mines, and the University of Nevada, Las Vegas will pursue three...
- This Project Grant award of $687,304 from the National Science Foundation's Biological Sciences (CFDA 47.074) program will enable the South Dakota School of Mines and Technology to acquire a BioLector XTM microbioreactor system. This specialized equipment can simultaneously grow and monitor up to 48 microbial cultures, replicating large-scale industrial fermentation conditions at a small scale. It will facilitate advanced research across disciplines such as microbiology, biochemical engineering,...
- This National Science Foundation (NSF) Research Traineeship (NRT) award to the South Dakota School of Mines and Technology (SDSM&T), in collaboration with the University of South Dakota, Black Hills State University, and Oglala Lakota College, will train 70 students, including 26 funded trainees, across master's and doctoral programs in data science, biosciences, and engineering. The $3,000,000 grant, awarded under the NSF's STEM Education program (CFDA 47.076), will prepare students to...
- This $199,280 federal Project Grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) will fund a workshop for artificial intelligence (AI)-powered materials discovery at the University of South Dakota (USD). The goal is to unite researchers from nine EPSCoR jurisdictions with experts in AI, engineering, materials science, physical science, and data science to create a world-class, data-driven materials research platform. The workshop will leverage...
- This federal Project Grant award, valued at $596,920 and provided by the National Science Foundation (NSF) Engineering program (CFDA 47.041), aims to develop a mechanism-informed AI platform to optimize biomanufacturing processes for life-saving biopharmaceuticals. Led by Northeastern University, the project will leverage emerging sensing technologies to efficiently decode the fundamental mechanisms underlying complex biomanufacturing systems. The goal is to create a flexible and robust AI-based...
- This $220,000 Project Grant award from the National Science Foundation (NSF) under the Computer and Information Science and Engineering (CISE) program supports the development of advanced computational methodologies for drug discovery and development. The primary awardee, the Regents of the University of Minnesota, will create a comprehensive generative AI framework capable of efficiently generating high-quality drug candidates with multiple desired properties. This initiative aims to expedite...
- The National Science Foundation Division of Emerging Frontiers awarded a $1,400,000 Project Grant under the Biological Sciences program (CFDA 47.074) to The Research Foundation For The State University Of New York, also known as Sponsored Projects Services, a non-profit research administration organization. This 5-year grant will fund collaborative research to investigate the role of environmental factors like temperature, heavy metals, and other contaminants in the development of...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 aims to develop a platform for detecting genetic antibiotic resistance motifs that can predict current and future susceptibility to therapeutics. The project will establish the feasibility of leveraging mutational signatures in bacterial DNA to identify antibiotic resistance status, including the potential for rapid development of multi-drug resistance. This approach...
- The National Science Foundation (NSF) awarded a $949,997 Project Grant to Iowa State University of Science and Technology under the Biological Sciences program (CFDA 47.074) to investigate the role of environmental factors in the development of antimicrobial resistance (AMR) in municipal wastewater treatment plants. The five-year research project, starting November 1, 2023, will conduct field, laboratory, and computational studies to determine how susceptible bacterial strains are replaced by...
This $999,470 federal Project Grant award from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) will support a collaborative research effort to develop methods for discovering and designing small molecules that can combat antibiotic resistance, biofilms, and aflatoxin contamination. The lead institution, South Dakota State University (SDSU), will partner with South Dakota Mines (SDM) and the University of Nevada, Las Vegas (UNLV) to leverage artificial intelligence (AI) and machine learning (ML) tools to accelerate the identification of bioactive compounds. The project will pursue three key thrusts: 1) activators inducing bacterial cell death, 2) inhibitors of biofilm maintenance proteins to mitigate biofouling, and 3) neutralizers of fungal toxins. The research will integrate computational modeling, high-throughput virtual screening, and experimental validation in bacterial and fungal assays. The award will also support infrastructure enhancements, including an AI/ML-driven screening platform across the three universities, development of teaching modules and lab kits for K-12 and undergraduate instruction, and expansion of biofilm and aflatoxin assay capabilities. This multi-institutional collaborative effort aims to advance human and animal health, prevent microbial corrosion in infrastructure, and enhance food safety.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $999.5k | 8/7/25 |