Project Grant 2316631
- The National Science Foundation (NSF) Division of Mathematical Sciences awarded a $200,000 Project Grant to the University of California, Davis (UC Davis) under the Mathematical and Physical Sciences program (CFDA 47.049). The 3-year grant, effective August 15, 2023, will fund research into the topology and infection dynamics of bacteriophage viruses. The project aims to provide a thorough characterization of DNA organization inside phage capsids and its delivery during infection, bridging...
- The Regents of the University of Minnesota, through the Office of Sponsored Projects Administration, has received a $200,000 Project Grant award from the National Science Foundation's (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049). The award, effective August 15, 2023 through July 31, 2026, will support collaborative research to characterize the topology and infection dynamics of bacteriophage viruses. Key focus areas include...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $273,652 to Phage Refinery LLC aims to develop a rapid and efficient parametric model for predicting the likelihood that a given bacteriophage (phage) will survive sufficiently long in the presence of an active immune system to be effective as a treatment against their target bacterial infection. The project will gather physical parameters and in-vivo persistence data for 400...
- The National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences awarded a $250,000 Project Grant titled "LEAPS-MPS: CONTROLLABLE SETS FOR NONLINEAR SWITCHED MODELS WITH APPLICATIONS TO INFECTIOUS DISEASES" to the Regents of the University of Idaho, performing the work through the University of Idaho. The two-year grant, awarded under CFDA 47.049 - Mathematical and Physical Sciences, aims to develop a mathematical framework for predicting the population dynamics...
- The National Science Foundation (NSF) awarded a $451,276 Project Grant to the University of Texas at Arlington (UTA) under the Mathematical and Physical Sciences (MPS) program (CFDA 47.049) for the project "Design of pH-Responsive Peptide Assembly for Acid-Activatable Antimicrobial Therapy." The project aims to develop self-assembling antimicrobial nanofibers that are activated in acidic environments, such as those found in infections, to effectively kill antibiotic-resistant...
- The National Science Foundation (NSF) Division of Mathematical Sciences awarded a $100,000 Project Grant to the Florida Institute of Technology Inc. (doing business as Florida TECH), a private university and non-profit organization located in Melbourne, Florida. This award is funded through the NSF's Mathematical and Physical Sciences program (CFDA 47.049), which aims to promote the progress of mathematical and physical sciences and strengthen the nation's scientific enterprise. The primary...
- The National Science Foundation (NSF) awarded a $802,161 Project Grant to the University of Massachusetts Medical School (UMass Medical) to study the structural mechanisms of bacteriophage (phage) infection and assembly. This 3-year grant, effective June 1, 2024, aims to advance the understanding of virus-host interactions, promote the development of effective antiviral strategies, and leverage phage-related applications. The research will focus on three aspects of the phage life cycle: virus...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 will fund a 3-year postdoctoral fellowship to research the adaptive response of bacteria to bacteriophage infection and high hydrostatic pressure. The fellow will develop novel fluorescence microscopy techniques to quantify bacterial growth, cell size, and morphology under these environmental stressors using model organisms E. coli, P. aeruginosa, and S. piezotolerans. The project...
- This Project Grant award of $410,977 from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) to Case Western Reserve University (CWRU) will fund research to develop methods for designing effective bacteriophage cocktails to precisely control the growth of unwanted bacteria in water systems. The key objectives are to: Identify genetic and transcriptomic markers of synergistic and antagonistic interactions between bacteriophages to guide the rational design of safe and...
- The U.S. National Science Foundation (NSF) awarded a $339,999 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to William Marsh Rice University in Houston, Texas. This 3-year award, beginning on September 1, 2025, will support collaborative research to develop mathematical modeling techniques for studying the spatiotemporal dynamics of intercellular signaling in engineered multicellular bacterial systems. The research aims to improve the predictability of...
The National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences awarded a $189,811 project grant to The College of Wooster under the Mathematical and Physical Sciences program (CFDA 47.049). The goal of this 2-year project is to develop an optimal combination phage cocktail and antibiotic therapy to treat antimicrobial resistant infections. The research will leverage mathematical models to identify characteristics of bacteriophages that show promise as therapeutic candidates, and will explore the treatment efficacies of single, double simultaneous, and double sequential administration strategies using three Pseudomonas phages. Researchers will incorporate both phage-killing and the evolution of bacterial phage resistance into the modeling framework to support the future development of combination phage and antibiotic therapies. The project will engage undergraduate students from diverse backgrounds in interdisciplinary research and enhance the institution's research environment in mathematical biology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $189.8k | 8/11/23 |