This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This $289,687 National Science Foundation project grant supports collaborative research to elucidate the mechanosensing mechanism of the adherens junction core complex through an integrated structural biology approach. Funded under the Biological Sciences program (CFDA 47.074), the research will employ static and dynamic neutron scattering, theoretical physics, and molecular simulation to determine the structure and dynamics of the mechanosensitive core complex that serves as a mechanosensing...
This $387,662 federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Duke University to elucidate the molecular mechanisms of cellular mechanosensitivity. The project aims to develop biosensors to study how protein phosphorylation affects the mechanical state of linker proteins, identify key mediators of mechanosensitivity, and evaluate the role of these...
This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $192,015 to Boise State University to conduct research aimed at quantifying the mechanical forces inside living cells and determining how changes in these forces impact cellular behavior and protein production. The overarching goal is to develop predictive models and technologies that can leverage mechanical forces to guide cellular differentiation and tissue regeneration, with potential...
This National Science Foundation project grant of $512,676 will fund research at Duke University from August 2022 to July 2025 under the Biological Sciences program (CFDA 47.074). The research aims to advance understanding of mechanosensitive channels in bacteria through single-molecule force spectroscopy experiments using an atomic force microscope. Investigators will observe the opening of individual mechanosensitive channels in living E. coli and B. subtilis bacteria in response to mechanical...
This $380,000 Project Grant award from the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research project between Northeastern University and the École Normale Supérieure in Paris, France. The project aims to develop a new generation of computational models to study eukaryotic cell motility, particularly how cells utilize "blebbing" and nuclear deformation to move through complex environments. The...
The National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences awarded a $399,755 Project Grant to the University of California, Santa Barbara (UCSB) under the Mathematical and Physical Sciences program (CFDA 47.049). The grant funds the development of new mathematical modeling paradigms and simulation software tools for investigating cell mechanics across multiple scales. This includes contributions from cell membranes and the cytoskeleton, and the roles of geometry,...
This $314,769 Project Grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) supports research that aims to advance the fundamental understanding of how cells and tissues communicate information about their mechanical environment. The award, effective from February 1, 2025 to January 31, 2030, will fund the development of new material platforms based on magnetic materials that can dynamically change local stiffness via magnetic fields. Experiments will explore how...
This National Science Foundation (NSF) Biological Sciences program project grant, awarded to Oregon Health & Science University (OHSU), aims to uncover the underlying biophysical mechanisms of directed cell migration. The $1,049,497 grant, with a period of performance from January 2024 to December 2027, will examine how actin cytoskeletal networks and adhesion receptors interact as interdependent subsystems to facilitate matrix-guided cell migration, which is crucial for tissue formation and...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $139,341 project grant to the Regents of the University of California, San Francisco (UCSF) under the NSF Biological Sciences program (CFDA 47.074). The 3-year grant, effective August 1, 2023, supports collaborative research to investigate the biomechanical mechanisms underlying wound resilience in the single-celled organism Stentor coeruleus. The research will leverage cell biology, microfluidics, and...
The National Science Foundation (NSF) Division of Physics awarded a $599,963 Project Grant to Duke University's Office of Research Administration Division to study the mechanosensitivity of the membrane-actin cortex interface in human and animal cells. This 3-year grant, running from August 2023 to July 2026, will develop innovative biosensors to investigate how the ezrin protein, which is involved in stem cell differentiation and cancer progression, responds to physical forces at the cell surface. The project will combine molecular engineering, cell biophysics, and computational modeling to elucidate how cells sense and respond to mechanical stimuli, with the goal of advancing fundamental cell biology as well as applications in regenerative medicine and disease treatment. This work aligns with the NSF's Mathematical and Physical Sciences program (CFDA 47.049), which promotes scientific discovery and engineering innovation.