This $227,265 Project Grant was awarded by the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), to The Regents of the University of California (UC Berkeley) on June 21, 2024. The project aims to map human retinal ganglion cell receptive fields at cellular resolution, directly connecting light stimulation of individual retinal photoreceptors to both the activity of retinal ganglion cells and the conscious perception reported by human subjects. This work will...
This National Science Foundation (NSF) Project Grant award of $240,000 from June 15, 2023 to May 31, 2026 supports an NSF Postdoctoral Research Fellowship in Biology under the Biological Sciences program (CFDA 47.074). The research aims to study the evolution and development of retinal specializations in fish, which can help understand how the environment and development shape the biology and evolution of the eye. The key products of this project include: 1) evolutionary genomics and...
This $839,338 Project Grant from the National Institutes of Health's National Eye Institute will fund research at Haverford College in Pennsylvania to investigate the genetic and neural mechanisms governing multisensory information processing and behavioral selection in zebrafish. Specifically, the researchers will use their zebrafish model to determine how the autism spectrum disorder-linked gene AP2S1 modulates visual and acoustic behavior as well as sensory integration. Through subcellular...
This Project Grant award from the National Eye Institute (NEI), under the federal grant program Vision Research (CFDA 93.867), provides $475,000 in funding to The Salk Institute for Biological Studies to characterize the connectivity and functional role of specific neural circuits in the mammalian visual system. The research aims to understand how retinal ganglion cell pathways carrying different types of visual information, such as motion-tuned and non-motion-tuned signals, influence the...
This four-year, $708,333 National Science Foundation project grant funds research at Georgia Tech Research Corporation to develop genetic and microfluidic technologies to direct the differentiation of human induced pluripotent stem cell-derived retinal organoids. Specifically, the researchers will apply genome-wide methods leveraging both cell differentiation and biomechanical properties to screen for pathways that regulate retinogenesis. Systems biology approaches will identify master...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $651,846 to The Johns Hopkins University to identify gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Müller glia. The research aims to determine how key transcription factors regulate developmental competence, proliferation, and neurogenesis in the retina. The project also investigates whether manipulating these...
The National Science Foundation Division of Integrative Organismal Systems awarded a three-year $997,100 Project Grant to the University of Massachusetts Amherst under the Biological Sciences program (CFDA 47.074) to conduct collaborative research on higher-order neural processing in the peripheral nervous system of the nudibranch mollusk Berghia stephaniae. The research team will develop an online portal containing the annotated connectome and neuronal atlas of Berghia's rhinophore complex...
This $800,000 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Louisiana State University (LSU) to investigate the unique visual system of the four-eyed fish Anableps anableps. The researchers will utilize cutting-edge techniques like bulk and spatial RNA sequencing, and ATAC-sequencing, to gain a mechanistic understanding of the genetic and developmental basis for the fish's split corneas and retinal adaptations...
The National Eye Institute (NEI) awarded a 5-year, $393,008 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of California, Davis (UC Davis) to conduct a study titled "Live Imaging-Based Molecular Dissection of a Successful Vertebrate RGC Axonal Regeneration Program." The project aims to systematically investigate how the frog Xenopus laevis is able to successfully regenerate damaged retinal ganglion cell (RGC) axons and regain vision,...
The National Science Foundation Division of Integrative Organismal Systems awarded $799,998 under the Biological Sciences program (CFDA 47.074) to the Regents of the University of California at Riverside. This five-year Project Grant will support research investigating the molecular mechanisms that guide neuronal migration and circuit formation in the developing cerebellum. Key products will include insights from genetic experiments using mouse models to examine the role of CRK-associated...