Project Grant 2527184
- This Project Grant award of $649,992.00 from the National Science Foundation's Engineering program (CFDA 47.041) supports research that aims to study how aortic valve leaflet tissue modifies its structure over time and how these changes are influenced by mechanical loading. The research focuses on developing new methods to measure how the material properties of the aortic valve leaflet vary across its surface and over time, as well as using advanced imaging techniques to study the leaflet's...
- This National Science Foundation (NSF) Project Grant under the Biological Sciences program (CFDA 47.074) provides $668,572 in funding to Northeastern University to conduct research on the molecular and biophysical mechanisms underlying contractile valve assembly and function. The research aims to characterize the inner structure and regulatory mechanisms of a donut-shaped contractile valve in the reproductive system of the nematode C. elegans, using advanced microscopy, genetic perturbations,...
- The University of Arkansas received a $414,982 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to develop a force-validated computational model of the human mitral valve for patient-specific surgical planning and intelligent medical device development. The project aims to enhance the durability of heart valve surgical repair techniques and replacement devices by ensuring the valve functions under the lowest possible stress. The...
- This National Science Foundation (NSF) Project Grant award under CFDA 47.041 (Engineering) supports the development of a new computational model to predict the complex interactions between ventricular assist devices (VADs) and the beating native heart. The goal is to create a "digital twin" of an experimental mock circulatory loop used for testing VAD safety and efficacy. This $195,291 award, effective August 1, 2024 through July 31, 2026, will result in a lumped parameter model that...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $640,562 to Duke University to develop advanced computational models and tools that simulate cardiovascular function and blood flow dynamics. The project aims to create "virtual replicas" of a patient's blood vessels and heart activity using everyday data from wearable sensors. These models will enable earlier detection of heart problems, more...
- This $250,120 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports collaborative research at Clemson University to investigate the effects of physical deformation on the proliferation and motility of single cells. The goal is to develop specialized microfluidic devices to simulate the tight spaces cells experience in the human body and study how physical stresses impact cellular behaviors like division and movement. This research...
- This Project Grant award of $506,803, provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), will fund research by the Research Foundation for the State University of New York (RF SUNY) to develop advanced multiscale modeling capabilities for predicting thrombus (clot) formation and its response to external loads. The goal is to create computational tools that can better forecast clot growth and rupture under varying blood flow conditions, such as pulsatile...
- Colorado State University will receive $337,430 through June 2030 from the National Science Foundation's Engineering grant program (CFDA 47.041) to conduct collaborative research on changes in right ventricle viscoelasticity under acute stress and chronic pulmonary hypertension. The research aims to improve understanding of the mechanical behavior and pumping function of the right ventricle by analyzing its passive viscoelastic tissue properties experimentally and computationally with disease...
- This federal Project Grant award from the National Science Foundation's Division of Civil, Mechanical, and Manufacturing Innovation (CFDA 47.041 - Engineering) provides $500,000 in funding to North Carolina State University to conduct fundamental research aimed at reducing blood clotting in medical devices. The key products and services to be delivered under this award include: 1) molecular dynamics simulations and interfacial spectroscopy to understand the role of hydration layers in preventing...
- This National Science Foundation (NSF) Project Grant award, under the Engineering program (CFDA 47.041), provides $279,376 to Washington University to conduct research on the mechanisms of right ventricular (RV) stiffening and its impact on cardiac health. The project aims to delineate and model the intra- and extra-cellular mechanisms contributing to RV myocardial stiffening using a combination of experimental and computational approaches. Specifically, the researchers will perform...
This $600,000 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) is funding a research project titled "BRITE RELAUNCH: BIOMECHANICS AND MECHANOBIOLOGY OF VENOUS VALVE DEGENERATION" at North Carolina State University. The project aims to generate new data and computer models on how the cells of venous valves respond to the mechanical forces associated with high blood pressure and tissue damage, which can lead to chronic venous insufficiency. The research seeks to improve fundamental understanding of these biological processes to broadly impact the design of replacement valves, heart surgery using veins, and therapies for chronic venous insufficiency and other vascular diseases. The award supports education, outreach, and workforce development initiatives, including activities for K-12 students and those at primarily undergraduate institutions. The project will run from October 1, 2025 through September 30, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $600.0k | 8/3/25 |