This three-year, $926,260 National Science Foundation project grant supports research investigating the genetic and evolutionary factors behind the loss of sperm flagella in weakly electric mormyrid fishes. Funded through the NSF's Biological Sciences program (CFDA 47.074), the award to Michigan State University will determine whether a partial gene deletion results in flagellar loss using CRISPR/Cas9 gene editing in zebrafish. It will also examine sperm-egg interaction and test hypotheses that flagellar loss evolved to conserve energy in mormyrid testes. A $50,000 subaward to The Washington University supports graduate student Ellen Urquhart in performing whole animal and testis respirometry experiments and tissue collection to evaluate the energetics hypothesis. The project's findings may provide novel insights into human ciliary diseases and support continued operation of an electric fish genomics database resource.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $926.3k | 3/16/23 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
RC115049WUS | The Washington University | Project Grant 2243230 | $165.7k | 6/13/23 |