Project Grant 2239162

Award Date 8/15/23
Completion Date 7/31/28
Dollars Obligated $566K
Federal Grant Program
47.041
Assistance Type
Project Grant
Place of Performance
Boston, MA 02215, USA
Similar Awards
This three-year, $2.97 million Project Grant from the National Institutes of Health's Trans-NIH Research Support program will support the development of a novel lung research platform to probe pulmonary (patho)physiology in real-time at the cellular level. Trustees of Boston University will receive funding to create the LungEx platform, which includes long-term ex vivo maintenance of mouse and human lungs under near-physiological conditions. A key innovation is a "Crystal" ribcage that...
The Trustees of the Stevens Institute of Technology received a $902,130 Project Grant award from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation on January 1, 2022 to support research titled "BIOMECHANICS OF TENSION-INDUCED LUNG TISSUE FRACTURE AND SUBSEQUENT PULMONARY AIR LEAK." The research is funded through the NSF's Engineering program (CFDA 47.041) to improve understanding of lung tissue biomechanics and fracture. Specifically, the grant...
The Trustees of Boston University were awarded a $286,932 project grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation to support research titled "COLLABORATIVE RESEARCH: INFERRING THE IN SITU MICRO-MECHANICS OF EMBEDDED FIBER NETWORKS BY LEVERAGING LIMITED IMAGING DATA." The two-year project beginning January 1, 2022 falls under the NSF Directorate for Engineering's $47.041 Engineering program, which seeks to improve quality of life...
The National Science Foundation awarded a $602,650 project grant to Northeastern University for research titled "ELUCIDATING THE ROLE OF COLLECTIVE CELL-MATRIX INTERACTIONS IN THE MECHANOBIOLOGY OF AIRWAY NARROWING." The five-year grant runs from July 1, 2021 through June 30, 2026 under the NSF Engineering Program (CFDA 47.041). The grant will fund research at Northeastern University in Boston, MA to improve understanding of how collective cell-matrix interactions influence airway...
The Trustees of Boston University will receive $338,457 from the National Science Foundation (NSF) through the agency's Engineering program (CFDA 47.041) to conduct research measuring and modeling particle enrichment in jet drops from bursting bubbles from July 1, 2021 to June 30, 2024. As part of the NSF's efforts to foster innovation and excellence in engineering research, this Project Grant will support Boston University researchers in improving understanding of the dynamics of bursting...
The University of Massachusetts Boston was awarded a two-year, $199,952 project grant from the National Science Foundation's Engineering program (CFDA 47.041) to conduct research investigating the biomechanical behavior of cell spheroids of varying sizes. The university will use microfluidics to systematically measure the viscoelastic mechanical properties of cell spheroids ranging from single cells to mesoscale multicellular spheroids 1 mm in diameter. It will also create a finite element model...
This $462,600 three-year Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will establish an REU (Research Experiences for Undergraduates) Site focused on translational biophotonics at Boston University. The program will engage 10 undergraduate students annually in research using light-based technologies to measure cells, tissues, and organs for improving human health. Key activities include laboratory-based research, seminars, and training in...
This National Science Foundation (NSF) Project Grant award, under the Federal Grant Program CFDA 47.041 (Engineering), provides $651,674 to the Trustees of Boston University to conduct fundamental research on the mechanics of elastogranular metamaterials. The research aims to understand how the interplay between localized confinement (such as cohesion, adhesion, and packing geometry) and elastic instabilities in slender structures interacting with granular matter enables the development of...
The University of Utah will receive $566,507 from the National Science Foundation (NSF) under the Biological Sciences federal grant program (CFDA 47.074) from July 2021 through June 2024. The funding will support research into pulmonary aerodynamic valves, their distribution in the lungs, and their functions. The NSF Biological Sciences program aims to advance the field and strengthen the national scientific enterprise through increased knowledge and understanding of major issues. This project...
This $476,886 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research at Boston University to develop computational models for predicting the spatiotemporal distribution of growth factors in tissue engineering scaffolds. The goal is to optimize scaffold designs to achieve optimal growth factor exposure profiles that improve tissue regeneration outcomes, particularly for cartilage repair. The research utilizes reaction-diffusion...

Trustees of Boston University received a $566,473 National Science Foundation Project Grant under the Engineering (47.041) federal grant program. The five-year award funds research utilizing a novel transparent ribcage platform termed LUNGEX to probe multiscale mechanobiology of pulmonary respiration-circulation coupling in real-time. The platform will allow unprecedented visualization of lung microphysiology dynamics at the cellular level across nearly the entire lung surface. Specific aims include investigating alveolar distension coupling with red blood cell trafficking and oxygen transport at the capillary level, determining the role of alveolar lymphatics in visceral lymphatic flow, and probing real-time mechanical interactions of immune cells with capillaries at the single cell level. The university will integrate this research with education of students at all levels in pulmonary biomechanics and mechanobiology.

Generated 3/5/24, 9:17 AM