Trustees of Boston University received a $566,473 National Science Foundation Project Grant under the Engineering (47.041) federal grant program. The five-year award funds research utilizing a novel transparent ribcage platform termed LUNGEX to probe multiscale mechanobiology of pulmonary respiration-circulation coupling in real-time. The platform will allow unprecedented visualization of lung microphysiology dynamics at the cellular level across nearly the entire lung surface. Specific aims...
This $136,050 Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to Trustees of Tufts College, doing business as Tufts University School of Medicine, seeks to characterize lung-resident B1 cells and investigate their impact on lung homeostasis during development. The research will determine if lung B1 cells have distinct transcriptional signatures, phenotypic properties, and tissue-specific antibody repertoires compared to...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,564,220 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, on Sep 17, 2024. The grant funds the development of an imaging-compatible pre-clinical ex vivo lung perfusion (EVLP) system to obtain structural, functional, and metabolic biomarkers of donor lung health. The project aims to use these...
This is a Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), under the Cardiovascular Diseases Research (CFDA 93.837) program. The $827,682 award will fund a comprehensive research project to develop advanced imaging techniques, including dynamic contrast-enhanced CT, dual-energy CT, and electrical impedance tomography, to characterize pulmonary perfusion and guide personalized treatment of acute respiratory distress...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $786,139 to The Trustees of the University of Pennsylvania to develop a technique for dynamically imaging lung function in free-breathing subjects using hyperpolarized 129Xe MRI. The goal is to enable a more physiologically relevant assessment of lung function, especially in patient populations with poor breath-hold tolerance. The project...
This $1,688,712 Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to Duke University supports research on how the microtubule-associated protein Tau mediates microtubule and mitochondrial dynamics to control cellular organization and alveolar epithelial repair in the lungs. The 5-year award, starting in August 2024, aims to investigate the role of Tau in the differentiation of type-2 alveolar epithelial cells into thin, large...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is funding research at Northwestern University to investigate the role of mitochondrial metabolism in alveolar epithelial cell differentiation and the development of lung fibrosis. The $616,000 award, effective September 1, 2024 through August 31, 2029, will support experiments using genetic mouse models to determine how mitochondrial...
The U.S. National Heart, Lung, and Blood Institute (NHLBI) awarded a $802,500 Cooperative Agreement grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Children's Hospital Medical Center in Cincinnati, Ohio. The grant supports the construction of a multi-scale 3D AI-powered map of genetic factors and cellular interactions driving normal and aberrant lung development in childhood interstitial lung disease (CHILD). The project will leverage single-cell and spatial...
This $940,320 Cooperative Agreement awarded by the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), supports a 5-year research project led by Vanderbilt University Medical Center to investigate the molecular mechanisms underlying chronic parenchymal lung diseases like pulmonary fibrosis and bronchopulmonary dysplasia. The project aims to develop a spatially-resolved molecular atlas of chronic lung diseases,...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,659,996 to the University of Southern California (USC) from April 1, 2025 to January 31, 2029. The funding supports research to investigate the role of the protein PDLIM2 in regulating alveolar macrophage function, which is critical for lung innate immunity, inflammation, and respiratory diseases. The research aims to elucidate the...
This three-year, $2.97 million Project Grant from the National Institutes of Health's Trans-NIH Research Support program will support the development of a novel lung research platform to probe pulmonary (patho)physiology in real-time at the cellular level. Trustees of Boston University will receive funding to create the LungEx platform, which includes long-term ex vivo maintenance of mouse and human lungs under near-physiological conditions. A key innovation is a "Crystal" ribcage that is transparent, enabling real-time volumetric optical microscopy of the lung surface. Using LungEx, researchers can visualize lung pathophysiology dynamics with unprecedented spatial and temporal resolution. The platform also facilitates precise control of respiratory, circulatory, biochemical and optogenetic parameters. Researchers will demonstrate LungEx's capabilities by probing immune responses to lung metastasis and viral infections like SARS-CoV-2 at early stages. Overall, LungEx is expected to transform pulmonary research areas such as disease pathogenesis, drug development, aging and transplantation.