The University of Texas at Arlington is receiving a $199,006 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) to develop a high-throughput single-molecule nanosensor to characterize the loading efficiency of gene delivery liposomes for use in future gene therapy clinical trials. The nanosensor will utilize a dual-nanopore architecture to rupture liposomes and analyze their genetic contents, providing improved accuracy in quantifying DNA dosage compared to current methods. This research aims to enable more effective future gene therapy treatments by addressing the challenge of ensuring uniform DNA loading in liposome-based gene delivery systems. The award period runs from September 1, 2024 to August 31, 2027. No subawards are planned under this grant.
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