Project Grant 2228410

Award Date 6/15/22
Completion Date 5/31/23
Dollars Obligated $100K
Federal Grant Program
47.084
Assistance Type
Project Grant
Place of Performance
Ithaca, NY, USA
Similar Awards
This $300,000 project grant from the National Science Foundation will fund research at Cornell University from October 1, 2022 to September 30, 2025. The award is provided through NSF's Engineering Biology and Health Cluster within the Directorate for Engineering, Biological Sciences and Biotechnology, under the CFDA program for Engineering. Specifically, researchers at Cornell University and Washington State University will work to develop new tissue engineering strategies for cartilage repair....
This $500,000 project grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation supports research titled "GOALI/COLLABORATIVE RESEARCH: INSTABILITIES AND LOCAL STRAINS IN ENGINEERED CARTILAGE SCAFFOLD" being conducted at Cornell University from January 1, 2022 to December 31, 2024. The research aims to improve understanding of instabilities and local strains in engineered cartilage scaffolds, with the goal of enabling innovation in cartilage...
This National Science Foundation project grant of $400,000 will fund research at Clarkson University from July 2022 to June 2024 under the Engineering (47.041) federal grant program. The research aims to establish animal models as ideal systems for studying the interplay between mechanics and biology in musculoskeletal tissue by examining bovine caudal intervertebral discs. Specifically, the grantee will use live-animal motion tracking combined with numerical modeling to estimate multi-axial...
This three-year, $1.2 million project grant from the National Science Foundation's Engineering program (CFDA 47.041) will support research at Washington State University and Cornell University to develop new tissue engineering strategies for cartilage regeneration. The researchers aim to stimulate adult stem cells to become mature chondrocytes for cartilage production through small molecules that interfere with bone cell differentiation genes. Real-time imaging will monitor cell growth...
This $605,253 Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the mechanical crosstalk between the intervertebral disc and facet joints during spinal degeneration and repair. The research aims to characterize the progression of facet osteoarthritis in an animal model following induced intervertebral disc degeneration, as well as...
The National Science Foundation (NSF) Division of Materials Research awarded Drexel University a $200,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049). The 2-year grant, effective from October 1, 2023, will fund research to establish the correlation between the structural and mechanical properties of lumbar spinal cages fabricated using fused filament fabrication (FFF) of polyetheretherketone (PEEK) and polyetherketoneketone (PEKK) polymers. The overarching...
The National Science Foundation awarded a $399,685 project grant to the University of California Irvine under the Engineering program (CFDA 47.041) to develop innovative cartilage tissue engineering strategies utilizing the microgravity environment of the International Space Station. The objectives of the three-year award beginning September 1, 2022 include employing microgravity conditions to enhance key processes in earth-based cartilage tissue engineering such as redifferentiation of expanded...
This $752,620 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS, CFDA 93.846 Arthritis, Musculoskeletal and Skin Diseases Research) supports research conducted by The Washington University aimed at developing injectable alginate hydrogel cell carriers to enhance the therapeutic potential of mesenchymal stem cells (MSCs) for intervertebral disc (IVD) repair. The research will focus on modifying alginate hydrogels to present...
This $476,886 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research at Boston University to develop computational models for predicting the spatiotemporal distribution of growth factors in tissue engineering scaffolds. The goal is to optimize scaffold designs to achieve optimal growth factor exposure profiles that improve tissue regeneration outcomes, particularly for cartilage repair. The research utilizes reaction-diffusion...
This National Science Foundation (NSF) Project Grant award, under the Engineering (CFDA 47.041) program, provides $400,000 to Cornell University to support an integrated mechanobiology framework for sculpting architected biological tissues. The key objectives are to uncover the mechanical principles driving connective tissue morphogenesis and to develop computational design tools that can instruct robotic micromanipulation to engineer desired tissue shapes, structures, and sizes. The 4-year...

Cornell University received a $100,000 Project Grant from the National Science Foundation to develop a tissue-engineered intervertebral disc with a biodegradable cage. The goal of the one-year project under the NSF Technology, Innovation, and Partnership's CFDA 47.084 program is to advance the commercial potential of a tissue-engineered solution to treat intervertebral disc degeneration. Intervertebral disc degeneration is a leading cause of disability in the United States, costing $100B annually to treat. The proposed technology utilizes a 3D printed biodegradable cage to provide mechanical support for soft tissue-engineered disc constructs until they integrate with the host tissue and can withstand in vivo loads. Finite element modeling aims to optimize the cage design for individual patient anatomy. If successful, the tissue-engineered disc with biodegradable cage could benefit patients through reduced pain and costs while simplifying surgical procedures for orthopedic and neurosurgeons.

Generated 1/7/24, 12:23 PM