The National Science Foundation awarded a $538,838 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to The Regents of the University of California, San Francisco for research titled "Collaborative Research: Mapping Protein-Membrane Interactions from Molecules to Cell-Level Dynamics." The research will develop multiscale models to map how individual protein structures and compositions interact with and deform cell membranes at varying scales, from...
This $208,784 federal Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research project to study the emergent dynamics and scaling laws of bioinspired lipid membranes. The University of Arizona, as the primary awardee, will integrate experimental methods such as neutron spectroscopy, NMR, and flicker spectroscopy with molecular dynamics simulations. This integrated approach aims to establish the...
This $659,728 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) will support the development of the BioMemBHub cyberinfrastructure. BioMemBHub is designed to advance modeling and analysis capabilities for biomembranes, proteins, peptides, and small molecules. The project will create an integrated platform consisting of seven web servers and three large databases to enable exploration of the structural and dynamic aspects of...
This Project Grant award of $410,939 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research at Clemson University to elucidate the biophysical mechanisms of membrane protein folding and stability. The project will use advanced single-molecule force spectroscopy techniques, such as atomic force microscopy, to probe how membrane proteins interact with cell membranes, maintain proper orientation, and achieve their final folded state during...
This $415,311 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), will fund research into the biophysical effects of reversible lipid modification of integral membrane proteins. Using computer modeling and simulations, Syracuse University researchers will study how attaching lipid chains affects the structure and interactions of membrane proteins. Specifically, the project will characterize the...
This award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $741,000 to the University of Chicago to develop a fast and accurate computational tool called UPSIDE for simulating the dynamics and structure of large membrane proteins involved in sensing environmental stimuli like force and heat. The research aims to enhance the understanding of how sensory membrane proteins in humans and animals function at the atomic level, which is crucial for addressing...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $757,389 Project Grant to the University of Texas at Austin to support research titled "Understanding Highly Heterogeneous Biological Membranes" from August 1, 2021 through July 31, 2024. This award will fund research into major problems confronting the nation through advancing the biological sciences, as outlined in the Biological Sciences program (CFDA 47.074). Specifically, the University of...
The National Science Foundation (NSF) awarded a $253,890 Project Grant under the Biological Sciences program (CFDA 47.074) to Western University of Health Sciences to conduct research on sensory membrane proteins. The goal is to develop computational tools capable of realistic simulations of how these proteins respond to external stimuli like pressure, heat, and sound. The research project, titled "Collaborative Research: Ultra-Fast Simulations of Sensory Membrane Proteins with Validation...
This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program provides $242,103 to the Massachusetts Institute of Technology (MIT) to conduct research exploring how proteins and lipids coordinate the formation and function of membrane-associated condensates. The goal is to gain a better understanding of how the cell surface is organized, which could lead to advancements in biotechnology, disease treatment, and our overall understanding of...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences and Division of Mathematical Sciences awarded a $550,000 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of Texas at Austin. The grant, titled "COLLABORATIVE RESEARCH: MODULUS: PROTEIN DROPLETS DRIVE MEMBRANE BENDING AND CYTOSKELETAL ORGANIZATION," seeks to improve understanding of how protein droplets interact with cellular membranes and the cytoskeleton. The...