The National Science Foundation (NSF) awarded a 5-year, $430,413 CAREER grant to Wayne State University for a project titled "COMPUTATIONAL DESIGN OF FLUORESCENT PROTEINS WITH MULTISCALE EXCITED STATE QM/MM METHODS." The project, funded under NSF's Mathematical and Physical Sciences (CFDA 47.049) program, aims to advance the understanding and rational design of new fluorescent protein sensors. The research will use classical molecular dynamics, excited state quantum...
This National Science Foundation (NSF) project grant under the Mathematical and Physical Sciences (CFDA 47.049) program provides $600,000 in funding to Professor Lei Zhu of the Florida State University Department of Chemistry and Biochemistry. The award supports research to understand the photophysical and photochemical properties of two categories of organic fluorescent dyes. The first category will focus on developing dyes capable of excited state proton transfer to produce excitation...
The National Science Foundation awarded a $138,000 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to identify a novel green fluorescent small molecule in the heterotrophic dinoflagellate Gyrodinium jinhaense AP17. The two-year award running from January 2023 to December 2024 will support postdoctoral research fellowship activities at Konstanz, Germany. The fellowship aims to determine the fluorescent molecule's structure, identify the underlying chemical and...
This $641,448 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports a research project led by Professor Yang Zhang at North Carolina State University. The project aims to advance the understanding and control of single-molecule fluorescence spectral heterogeneity across diverse organic fluorophore families, including rhodamine, boron dipyrromethene (BODIPY), cyanine, and squararine dyes. The key research...
This $650,000 federal Project Grant awarded by the National Science Foundation (NSF) Division of Chemistry supports the research of Dr. Raphael Florentino Ribeiro of Emory University. The award, effective December 1, 2023 through November 30, 2028, aims to develop new theoretical approaches and computational methods for investigating chemical phenomena in microenvironments that confine light and interact strongly with matter. The research will computationally explore strategies to achieve...
The National Science Foundation (NSF) awarded a $437,749 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of North Carolina at Charlotte. The grant supports a research project to investigate a new class of luminescent protein materials and their potential applications in imaging, sensing, and biological tracking. The project aims to characterize the chemical and physical properties of known luminescent protein-metal compounds, and leverage...
The National Science Foundation (NSF) awarded a $740,797 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to the Regents of the University of California, San Francisco (UCSF) to develop and test new methodologies for the rational design of minimalistic light-switchable single-domain proteins. The goal is to engineer these proteins to bind specifically to target proteins in only one photoswitchable chromophore state, allowing for precise spatial and temporal control...
This Project Grant award, valued at $555,000.00 and awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports research at the Massachusetts Institute of Technology (MIT) focused on developing advanced hybrid J-aggregate nanostructures. The primary objectives are to: Investigate how silica matrices influence the brightness, stability, and excitonic behavior of J-aggregate fluorophores, and explore solvent tunability through surface...
This Project Grant award, valued at $133,476.00, was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The award supports Grant Rotskoff of Stanford University in developing machine learning models to predict and analyze the fluctuations of biomolecules, such as proteins. The overarching goal is to construct accurate configurational ensembles of diverse molecular systems at a lower...
This $326,557 Project Grant award, funded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049), supports the development and characterization of novel biomaterials made from folded globular proteins. The award aims to: 1) experimentally characterize the mechanical response of the protein building blocks as a function of force, tethering geometry, and solution environment; 2) directly relate protein domain unfolding to the mechanical response...