This National Science Foundation Project Grant of $492,743 will fund research into the impacts of intracellular and extracellular hydraulic environments on mammalian cell migration in confined spaces. Awarded on October 15, 2022 under the Engineering program (CFDA 47.041), the funding will support mathematical modeling to decipher the coupled effects of fluid interaction with cellular structures on cell behavior in confined migration. The awardee, the Research Foundation for the State University...
This National Science Foundation (NSF) Biological Sciences program project grant, awarded to Oregon Health & Science University (OHSU), aims to uncover the underlying biophysical mechanisms of directed cell migration. The $1,049,497 grant, with a period of performance from January 2024 to December 2027, will examine how actin cytoskeletal networks and adhesion receptors interact as interdependent subsystems to facilitate matrix-guided cell migration, which is crucial for tissue formation and...
This $1,648,162 federal Project Grant award, funded by the National Science Foundation's Biological Sciences program (CFDA 47.074), supports research to uncover how the chemoattractant receptor CAR1 and its associated signaling dynamics regulate gradient sensing and directed cell migration in the model organism Dictyostelium discoideum. The project aims to elucidate the molecular mechanisms by which CAR1 phosphorylation events modulate the interaction with the G-protein G2, and how this...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, is funding a research project titled "Investigating the Role of Signaling Feedback in Directed Cell Migration." The $147,656 award, with a project period from December 2024 to September 2027, will support investigations into the mechanisms by which cells regulate signaling pathways to control navigation during cell...
This Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049), focuses on developing a new generation of computational models to study eukaryotic cell motility, especially in complex geometries. The $380,000 award, granted to Northeastern University, supports a joint experiment-theory project to gain a quantitatively predictive understanding of cell motility processes, including how cells utilize "blebbing" and...
This $409,375 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to determine how membrane fluidity regulates embryonic cell migration. The research, conducted by The Johns Hopkins University, aims to understand how migrating cells actively regulate local membrane fluidity to orient cell migration and position receptor proteins necessary for chemotaxis. The work will utilize...
This Project Grant award, provided by the National Science Foundation's Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research between Indiana University Indianapolis and Purdue University to develop a novel multi-scale 3D mathematical model to simulate cell migration. The $200,000 award will enable the researchers to integrate experimentally measured intracellular tension data into the model to better understand how external environmental factors, such as...
This Project Grant from the National Science Foundation provides $138,000 to support a Postdoctoral Fellowship in Biology for fiscal years 2022 through 2024. The fellowship funding is awarded under the Biological Sciences program (CFDA 47.074) to broaden participation of underrepresented groups in biology. The fellowship will support research and training to advance understanding of how maternal microbial exposures during development promote tolerance for beneficial microbes and protection...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded Northeastern University a $100,000 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to support research on "The Biophysics of Collective Cell Locomotion" from December 15, 2021 through December 31, 2023. Through this funding, Northeastern University researchers in Boston, MA will investigate the major problem of understanding the biological sciences by examining the...