Project Grant 2209271
- This federal Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to create innovative tools to understand neurodegeneration in glaucoma blindness. The $600,000 award, with a project period from Jul 1, 2025 to Jun 30, 2030, supports the development of an integrated platform that combines bioengineering tools and neurobiological studies. Key components include: (1) an injectable microbead-based in vivo flow occlusion model to replicate...
- This Project Grant award from the National Science Foundation (CFDA 47.041 - Engineering) provides $597,232.00 to the University of Illinois to develop a new imaging technique called "intrinsic signal optoretinography" for detecting early functional biomarkers of Alzheimer's disease in the retina. The research aims to establish this noninvasive, quantitative method for measuring changes in the retina that could indicate neurodegeneration in the brain before structural damage is...
- This $417,162 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research on using optical techniques to detect early signs of glaucoma, the leading cause of irreversible blindness worldwide. The University of Houston System, the grantee, will conduct research to determine if changes in the birefringence (optical properties) of the lamina cribrosa and posterior eye structures can serve as sensitive early indicators of glaucoma before structural damage...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $589,056 to the Regents of the University of Michigan, doing business as the University of Michigan-Dearborn, to study the biomechanics of aqueous fluid flow in the eyes' veins. The project aims to determine velocity profiles in the aqueous veins, measure strains in vein walls and adjacent sclera, and investigate correlations between vein flow, outflow facility, vein dilation, and...
- This $617,201 Project Grant awarded by the National Eye Institute's Vision Research program aims to leverage innovative tools from engineering, AI, and advanced optical coherence tomography (OCT) imaging to directly observe and unveil the specific mechanical insults to retinal ganglion cell axons that contribute to vision loss progression in glaucoma patients. The research team from Emory University intends to monitor glaucoma patients longitudinally to identify where these axonal insults,...
- This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program totaling $100,000 aims to develop a computational solution to evaluate optic nerve function. Specifically, the University of Nevada, Reno will use the funding to potentially create an affordable, convenient head-mounted display capable of remotely and routinely assessing the health of the optic nerve through afferent pupillary defect tests. This screening tool may allow doctors, including...
- This $174,520 Project Grant awarded by the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program supports the development of an advanced AI model to identify glaucoma-susceptible retinal ganglion cell subtypes using large-scale single-cell sequencing data. The research at Appalachian State University aims to uncover hidden patterns in genetic datasets to better understand which retinal cell types are most vulnerable to glaucoma, a leading cause of...
- This $387,428 Project Grant from the National Eye Institute (CFDA 93.867 - Vision Research) aims to investigate fundamental mechanisms driving optic nerve sensitivity to elevated intraocular pressure, a major risk factor for optic nerve damage in glaucoma. The project will use 3D bioengineering tools, transgenic animal models, and ex vivo donor optic nerve head tissue to test the hypothesis that transient biomechanical strains prime optic nerve head astrocytes to develop greater glaucomatous...
- This Project Grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) provides $285,122 to the University of Louisiana at Lafayette (UL Lafayette) to conduct basic research in artificial intelligence (AI) for cost-effective image analysis. The two-year project, running from February 2026 to January 2028, will support a faculty fellowship and graduate student training to develop novel AI frameworks that can adapt hospital-grade medical images to...
- The Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) supports the development of an accurate, non-invasive, and automated 24-hour intraocular pressure (IOP) monitoring device. The overarching goal is to create a wearable IOP monitor that can improve the clinical management of glaucoma, the leading cause of irreversible blindness. The $713,964 award will fund research activities over a 5-year period from March 2025 to February 2030 at the University of California,...
This $976,308 National Science Foundation project grant funds the University of Miami to develop a novel fundus multiwavelength imaging device for simultaneous multiwavelength imaging of the retinal nerve fiber layer. The goal is to design, construct, and validate a non-contact optical method that can sensitively detect early glaucoma damage through in vivo measurement of retinal spectral reflectance changes. Specifically, the University of Miami will design and construct a new fundus imaging modality to explore retinal nerve fiber layer reflectance spectra at visible and infrared wavelengths. Researchers will validate the device's measurement capabilities by comparing in vivo and in vitro reflectance spectra in normal rat retinas. They will also study retinal nerve fiber layer reflectance spectra in glaucomatous rat retinas using an animal model of the disease. This work builds on the investigators' prior in vitro experiments and has the potential to significantly impact early glaucoma diagnosis and medical treatment monitoring. Funded under the NSF's $976K Engineering grant program (CFDA 47.041), this project supports the foundation's mission to improve engineering research and education.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $488.2k | 6/30/22 |