The National Science Foundation awarded Kennesaw State University Research And Service Foundation, Inc. a $330,011 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to support research titled "RUI: TRANSCRIPTION FACTOR DISCOVERY IN THE EXTREMOPHILE THERMUS THERMOPHILUS." From July 1, 2021 to June 30, 2024, the Foundation will conduct basic research to identify transcription factors in the extremophile bacterium Thermus thermophilus. This work aims to...
This $1,050,000 Project Grant, awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), aims to study how extreme environments shape the regulatory networks of transcription in microbes called archaea. The research project, conducted by Duke University, will focus on haloarchaea - a group of archaea that thrive in extremely salty environments. The project's key objectives are to: (1) use genetics, genomics, and statistical modeling to compare the architecture...
This three-year Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences totals $1,512,792 to fund research at Louisiana State University examining the gene regulatory networks affected by purine catabolites in bacterial pathogens. The research aims to identify additional transcription factors in Burkholderia thailandensis responsive to urate and xanthine, which accumulate in host tissues during infection due to production of reactive oxygen species....
The National Science Foundation (NSF) Division of Integrative Organismal Systems awarded a 4-year, $2,670,305 Project Grant titled "TRTECH-PGR: REPROGRAMMING THE PLANT CELL WITH TRANSCRIPTION FACTORS" under the Biological Sciences federal grant program (CFDA 47.074). This project aims to systematically assess the effects of ectopically expressing thousands of maize transcription factors on gene expression and physiological responses in plant tissues. The research will use...
This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
The National Science Foundation awarded the University of Georgia Research Foundation, Inc. a $299,072 project grant under the Biological Sciences federal grant program (CFDA 47.074). The grant will support comparative single cell transcriptomics and regulomics research from June 2023 to May 2025. Specifically, the foundation will utilize cutting-edge omics techniques to discover the regulatory components of monoterpene indole alkaloid biosynthesis in two plant species. Researchers will...
The National Science Foundation (NSF) awarded a $300,000 Project Grant under its Biological Sciences program (CFDA 47.074) to the Georgia TECH Research Corporation for the "TOOLS4CELLS: EAGER: A MOLECULAR PURSUIT FOR THE ENGRAM: MICROFLUIDIC TEMPORAL TRANSCRIPTOMICS FOR SINGLE CELL LEARNING" project. This 2-year effort aims to develop innovative microfluidic tools and workflows to investigate the role of non-coding RNA in learning and memory storage in single-celled organisms. Key...
This Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $300,000 to the University of Kansas Center for Research Inc. from February 1, 2023 to January 31, 2025. The award will support research investigating delivery and trafficking of DNA introduced to cells from environmental sources using the genetically tractable organism Caenorhabditis elegans. The project aims to gain new...
This $240,000 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) funds a postdoctoral research fellowship to investigate the role of genome organization on de novo gene origination. The research aims to test a new theoretical model explaining the process of new gene evolution, by examining how the genome's structural features influence the birth of genes that arise from non-coding regions. The key components of the research include: 1)...
This Project Grant award of $1,199,999.00 from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program supports research on DNA N6-adenine methylation (6mA) in the unicellular eukaryote Tetrahymena thermophila. The project aims to map 6mA across the Tetrahymena genome using advanced DNA sequencing techniques and elucidate the molecular mechanisms that regulate 6mA deposition, particularly in the context of transcription and chromatin. This research will...