The National Eye Institute (NEI), under the Department of Health and Human Services, has awarded a Project Grant titled "Neural Mechanisms of Flexible Visual-Oculomotor Decision Rules" to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The $1,969,806 grant, awarded on September 1, 2024, supports research aimed at understanding the neural mechanisms that implement computational components of high-order visual processing, which are key building blocks of cognition. The project has three specific aims: 1) characterizing flexible decision rule use by monkeys, 2) identifying correlative relationships between neural activity in the oculomotor pathway and decision rules on single trials, and 3) identifying causal relationships between neural activity in specific brain regions and decision rules. The research leverages a novel theoretical framework, task design, and multi-level neural measurements and manipulations to provide new insights into the circuit mechanisms controlling when and how deliberative information processing leads to action commitments. The findings are expected to help establish a foundation for investigating cognitive impairments associated with dysfunction of the cortico-basal ganglia pathway.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $617.0k | 4/11/25 | ||
| Not listed | $676.4k | 7/31/24 | ||
| Not listed | $676.4k | 7/31/24 |