The University of California, Davis (UC Davis) received a $389,525 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) for a 5-year research project titled "CAREER: Mechanisms and Consequences of Epigenome-Recruited DNA Repair Systems in Plants." The project aims to study newly discovered DNA repair mechanisms in plants that could help protect critical genomic regions from harmful mutations. Researchers will leverage advanced...
This Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049), provides $159,819 to Dr. John Chaput at the University of California, Irvine (UC Irvine) to investigate the mechanism of DNA synthesis using advanced X-ray crystallography. The project aims to capture atomic-level "snapshots" of the DNA synthesis process, which will be assembled into an animated model to elucidate the precise steps involved. This...
This $663,956 Project Grant award from the National Science Foundation's (NSF) Division of Chemistry, through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program, supports Professor Norbert Reich at the University of California, Santa Barbara in studying a new DNA recognition mechanism involving DNA strand separation. The key products and services to be delivered under this 3-year award include: Investigating the mechanism by which the bacterial DNA adenine...
This $150,000 Project Grant awarded by the National Science Foundation's Mathematical and Physical Sciences (CFDA 47.049) program funds research at Vanderbilt University to elucidate the molecular mechanisms of DNA repair by a newly discovered bacterial enzyme. The project aims to understand how this enzyme protects microbes against toxic natural products, with the long-term goals of elucidating bacterial interstrand DNA crosslink repair pathways and discovering new genotoxic agents with...
This Project Grant award, totaling $246,424.00, was provided by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) federal grant program. The award is funding research at the University of California, Santa Barbara (UCSB) to define the initiation and early steps of DNA recombination at double-strand breaks. The project leverages novel methods to understand how cells choose different DNA repair mechanisms, with a focus on recombination, which has broad...
This Project Grant award of $480,000 from the National Science Foundation's (NSF) Division of Chemistry was made to Virginia Commonwealth University (VCU) to study the ultrafast molecular dynamics of conformational isomers. Professors Katharine Tibbetts and Ka Un Lao at VCU will use advanced laser techniques and molecular simulations to investigate how the specific conformations, or shapes, of complex molecules impact their chemical reaction pathways and photochemical degradation processes....
This Project Grant award, funded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049), aims to advance DNA-encoded chemical library (DECL) technology. Professors Jennifer Schomaker and Jeffrey Martell of the University of Wisconsin-Madison, along with Dr. Jing Chai at GlaxoSmithKline (GSK), are developing new oxidative transformations that can be conducted on DNA to significantly expand the structural diversity and...
This $900,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project led by North Carolina State University to unravel the mechanisms behind the workings of the DNA mismatch repair systems. The research aims to elucidate the role of atypical nucleic acid structures, such as three-way junctions and R-loops, in driving the expansion of simple sequence repeats (SSRs) within the genome, which is a...
This National Science Foundation project grant of $550,461 will fund research at the University of California, Davis from July 2022 to June 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). Professor Tantillo of the UC Davis Department of Chemistry will use computational chemistry methods to advance the fundamental understanding of reaction mechanisms and reactivity principles in organic chemistry. Specifically, the research will construct new mechanistic models to explain...
This Project Grant award, funded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), supports research at the University of Utah to develop chemically tunable models of the cellular glycocalyx - the sugar and protein coating on cell surfaces. Led by Professor Jessica Kramer, the $543,251 project from September 2024 through August 2027 aims to create synthetic mucin glycoproteins to engineer the...