This three-year, $1,368,422 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports the development of cryogenic electron microscopy (cryo-EM) to study phase separation in lipid membranes. Frederick A. Heberle of the University of Tennessee and M. Neal Waxham of the University of Texas Health Science Center at Houston will optimize cryo-EM imaging techniques to visualize nanoscale lipid raft domains in cell membranes. Goals include determining the minimum detectable raft size, developing freely available analysis tools, and training students. A $273,688 subaward to UT Health supports all aspects of cryopreservation, cryo-imaging, cryo-tomography, and initial image processing led by Dr. Waxham to integrate his work with Dr. Heberle's analysis programs. Insights on lateral heterogeneity in complex lipid-protein mixtures could further understanding of cell membrane organization and function.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $684.2k | 6/22/22 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
A230116S001A01S | University Of Texas Health Science Center At Houston | Project Grant 2204126 | $226.0k | 2/16/24 | |
A230116S001S | University Of Texas Health Science Center At Houston | Project Grant 2204126 | $113.0k | 9/11/22 |