The National Science Foundation Division of Chemistry awarded a $494,550 Project Grant to the University of Georgia Research Foundation to support research investigating new protein post-translational modifications derived from valine metabolism. Under the Mathematical and Physical Sciences federal grant program (CFDA 47.049), principal investigator Y. George Zheng and early career trainees will identify and validate two novel post-translational modifications, lysine methacrylylation and cysteine S-2-carboxpropylation, derived from reactive metabolites in valine metabolism. Researchers will develop chemical probes to detect these modifications at proteomic scales and investigate dynamic controls and downstream effects. This work aims to expand understanding of how valine metabolites contribute to protein regulation and signaling, with the results advancing the molecular-level characterization of the human proteome and post-translational modification roles. The award was issued on December 15, 2022 for completion by January 31, 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $494.6k | 5/24/22 |