Project Grant 2153599
- The National Science Foundation (NSF) awarded a $100,000 Project Grant to Rutgers, The State University under the Mathematical and Physical Sciences (MPS) program (CFDA 47.049). The 3-year grant supports a collaborative U.S.-France research project to develop new experimental and analytical methods for probing the heterogeneity of biological systems at the molecular level. Key deliverables include: 1) advanced high-speed atomic force spectroscopy techniques to study the complex structural...
- This Project Grant award from the National Science Foundation Division of Biological Infrastructure provides $125,000 to Brown University in collaboration with the University of Southern California to develop an electromagnet-integrated optical microscope stage with biocompatible magnetogel. The stage will enable simultaneous imaging and manipulation of biological systems to investigate how mechanical forces influence biological processes. Under the Biological Sciences (CFDA 47.074) federal...
- This National Science Foundation Project Grant of $419,750 will fund research at Washington University in St. Louis from August 1, 2022 to July 31, 2025 to study how living cells move across dissimilar physical environments and retain mechanical memories of prior environments. Specifically, the award will integrate experiments and computational modeling to examine how forces generated by cells modify their surroundings in two mechanically different environments during migration. This will reveal...
- This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $240,146 to the University of Alabama to conduct collaborative research on the effects of cellular deformation on the proliferation and motility of single cells. The research aims to engineer specialized microfluidic devices that simulate the tight spaces cells encounter in the human body, enabling the observation of how physical stress impacts cell division, movement, and...
- This federal Project Grant award of $200,000, made by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041), aims to integrate non-viral CRISPR gene activation and deep learning to understand the impact of cell manipulation and gene activation on stem cell differentiation. The key objectives are to: (1) decouple the effects of cell transfection and CRISPR-mediated activation (CRISPRa) on mesenchymal stromal cell (MSC) therapeutic capacity, and (2) bridge the gap...
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
- Lehigh University was awarded a $769,298 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences on July 15, 2021 to complete work by June 30, 2024. The grant falls under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise through increasing knowledge and understanding of major problems. Through this funding, Lehigh University will conduct molecular...
- The National Science Foundation (NSF) awarded a $630,000 Project Grant under the Biological Sciences (CFDA 47.074) federal grant program to the University of New Mexico (UNM) to develop an advanced optical microscopy system. The project aims to significantly improve the study of protein clustering and interactions on cell membranes, which could advance the understanding of cell signaling and related diseases like cancer. The highly interdisciplinary research will combine the MINFLUX and modal...
- This Project Grant from the National Science Foundation's Division of Civil, Mechanical, and Manufacturing Innovation, under the Engineering program (CFDA 47.041), provides $147,630 to The Ohio State University Office of Sponsored Programs from October 1, 2022 to April 30, 2023. The funding will support research investigating how mechanical forces are transmitted within cells through the linker of nucleoskeleton to cytoskeleton (LINC) complex. The principal investigator will develop novel...
- This CAREER award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will provide $314,769 to the University of Delaware to support research advancing the fundamental understanding of how cells and tissue communicate information about their mechanical environment. The project aims to develop new material platforms based on magnetic materials that can dynamically change local tissue stiffness to mimic biological events and measure the resulting mechanobiological...
This $300,000 project grant from the National Science Foundation Office of International Science and Engineering (NSF OISE) will support the development of advanced imaging techniques and innovative microscopic probes to determine how biological cells respond to force. Awarded on May 15, 2022 to Lehigh University, with completion by April 30, 2025, this funding enables a collaboration between Lehigh University faculty and researchers at the University of Bordeaux in France. Through this collaboration, 4-6 U.S. graduate and undergraduate students per year will conduct research toward their Ph.D. or senior thesis under joint supervision, working in Bordeaux laboratories during the summer and at Lehigh for the rest of the year. Students will develop multiscale microrheology to investigate mechanotransduction in organoids, time-lapse confocal imaging of stem cell differentiation in 3D-printed scaffolds, and magnetic nanoparticle-mediated transport of membrane-bound proteins on supported membranes. This work aims to advance understanding of stem cell differentiation and cell migration in complex 3D environments, in alignment with the NSF OISE goal of strengthening international partnerships to advance scientific discovery.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $300.0k | 3/11/22 |