Project Grant 2142914

Award Date 9/1/24
Completion Date 8/31/28
Dollars Obligated $554K
Federal Grant Program
47.078
Assistance Type
Project Grant
Place of Performance
TEMPLE TERR, FL 33617, USA
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This Project Grant award from the National Science Foundation's Polar Programs (CFDA 47.078) supports a collaborative research effort focused on studying the ecology of an Antarctic ascidian (sea squirt) and its symbiotic microbiome that produces the natural product palmerolide A (PALA). The $734,554 award to the Nevada System of Higher Education's Desert Research Institute will investigate the distribution, chemical diversity, and biological roles of the ascidian-microbiome-PALA association...
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This National Science Foundation (NSF) Project Grant award under the Polar Programs (CFDA 47.078) provides $554,121 to the University of South Florida to study the ecology of an Antarctic sea squirt and its associated microbiome. The key objectives are to:

  1. Characterize the microbiome composition, metabolome, and mitochondrial DNA of the Antarctic sea squirt Synoicum adareanum at sites in the Antarctic Peninsula and McMurdo Sound.

  2. Use a multi-omics strategy to comprehensively examine the Synoicum microbiome and its relationship to the production of the natural product palmerolide A (PALA).

  3. Assess the role of PALA in modulating the activity of the proton-pumping enzyme V-type H+-ATPase in the host sea squirt tissues and the overall ecophysiological effects.

This 4-year award, effective September 1, 2024, aims to advance the understanding of this intimate host-microbe association in the Antarctic marine ecosystem and explore the potential biomedical applications of the PALA natural product.

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