Project Grant 2141135
- The National Science Foundation (NSF) awarded a $450,000 Project Grant titled "BIOCENSORS: PARSING OUT THE GENETIC PAYLOAD OF VIRUSES BY DIFFERENTIAL BIORECOGNITION OF CAPSID FEATURES" under the NSF Engineering program (CFDA 47.041). The project, led by North Carolina State University, aims to develop a biosensing technology that can detect defective viral particles in gene therapy applications. The key objectives are to study ligand interactions with full and empty viruses,...
- The National Science Foundation (NSF) awarded a $331,189 Project Grant under its Technology, Innovation, and Partnerships (CFDA 47.084) program to the University of Central Florida Board of Trustees. The 4-year grant, effective April 1, 2025, is focused on developing an affordable, portable platform for rapid virus detection. The innovation combines protein engineering to create stable enzymes for isothermal virus amplification, with electrochemical biosensors and microfluidics, enabling virus...
- The National Science Foundation (NSF), under its Engineering program (CFDA 47.041), awarded a $429,832 Project Grant to the University of Massachusetts (UMass) to develop a novel method for rapid and sensitive detection of nucleic acids such as DNA and RNA. The main objectives of the 5-year project are to: Determine the nanomechanoelectrical transduction principle of nucleic-acid nanostructures tethered to a graphene transistor and oscillating in an electric field. Achieve rapid,...
- The National Science Foundation awarded a $230,000 Project Grant to the Regents of the University of Minnesota under the Engineering federal grant program (CFDA 47.041) to develop a biosensing platform for rapid sorting, trapping, and analysis of extracellular vesicles and viral specimens. Over a three-year period ending in August 2025, the University will combine graphene electrodes and photonic waveguides to create a "waveguide-integrated graphene nano-tweezers" platform. This...
- This $447,747 Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) to Trustees of Boston University will develop a novel plasmonic nanosensor system to detect two important classes of RNA molecules - microRNA (miRNA) biomarkers and SARS-CoV-2 viral RNA. The sensor platform uses DNA structures with nanoparticle probes that undergo conformational changes when binding to target RNAs, altering the plasmonic coupling signal which is detected via two-color...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award for $275,000 will support the development of a plasmonic nanopore sensor device for quality control of adeno-associated viruses (AAVs) used in gene therapy. The proposed device will enable accurate characterization of AAV payload (single-stranded DNA, double-stranded DNA, or empty) at low, pre-scale-up concentrations to optimize formulations. The project aims to demonstrate the...
- The National Science Foundation awarded a $250,000 Project Grant to the University of Pittsburgh under the Engineering federal grant program (CFDA 47.041) to develop a biosensor platform for rapidly sorting and analyzing nanoscale vesicles and viruses. The three-year award will support the design and demonstration of a waveguide-integrated graphene nano-tweezers platform that combines transparent dielectrophoretic graphene electrodes and silicon nitride photonic waveguides. By integrating...
- This CAREER award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports an integrated research and education project to address fundamental and applied challenges in solid-state nanopore-based single molecule counting platforms for point-of-care nucleic acid testing. The $435,054 award, effective from January 1, 2025 to May 31, 2026, aims to develop a fully integrated solid-state nanopore digital counting system for decentralized nucleic acid testing...
- The National Science Foundation awarded a $220,000 Project Grant to the University of Connecticut under the Engineering (47.041) federal grant program. The award will fund development of a compact, field-portable biophotonics instrument for automated analysis and identification of blood cells impacted by COVID-19. The instrument aims to provide real-time sensing and diagnosis capabilities with high accuracy, specificity and sensitivity for potential early detection of COVID-19 infections. It...
- This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...
This Project Grant from the National Science Foundation's Engineering Directorate (NSF ENG) provides $249,829 to Northeastern University to develop an integrated platform for high accuracy measurements of viral particle count and infectious titer. The platform will combine nano-pore technology to identify viral particles based on biophysical properties with single-molecule RNA fluorescence in situ hybridization to discriminate individual molecules of viral RNA in infected cells. This will enable the platform to quantify total particle numbers, measure genome-containing units, and assess infectivity of viral samples. The platform aims to address limitations in current viral quantification techniques by providing a standardized, precise, and non-cell line dependent method for measuring critical parameters like viral density, infectivity, and replication efficiency. The work directly supports NSF ENG's mission to foster innovation and excellence in engineering research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.8k | 1/25/22 |