This $487,795 award from the National Science Foundation (NSF) Engineering grant program (CFDA 47.041) supports Arizona State University in developing innovative ex vivo models of the tumor microenvironment (TME). The project aims to mechanistically understand how biophysical cues and signaling between stromal and immune cells contribute to the transition of tumor cells into an invasive phenotype, as well as explore how stromal cell function induces pathway signatures in tumor cells leading to...
This $429,114 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) will fund the development and validation of a first-of-its-kind multi-tissue on-a-chip breast-skin platform. The platform will feature integrated blood and lymphatic vasculature to study the spatial and temporal processes of lymphovascular space invasion (LVSI), dermal lymphatic invasion (DLI), and skin metastasis in breast cancer. The central hypothesis is that the cross-talk...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This $575,000 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research at the New Jersey Institute of Technology (NJIT) to study how the microstructure and interstitial fluid pressure gradients within a bioprinted tumor-on-a-chip model can modulate the invasive behavior of cancer cells. The project aims to use light-assisted bioprinting and microfluidics to construct a tunable solid tumor model, and then quantify the...
This three-year, $681,444 National Science Foundation project grant supports collaborative research to develop tumor-mimetic collagen hydrogels for testing the role of structural cues on cancer cell migration. The Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the funding under the Engineering program (CFDA 47.041), which aims to foster innovation and excellence in engineering research. The Rochester Institute of Technology will receive the award to create a...
This $544,475 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to develop an in vitro cancer metastasis model system using decellularized organ-specific tissue (biomatrices) to study organ-specific cancer metastasis. The University of Texas Southwestern Medical Center, the awardee, hypothesizes that the biomatrices can recapitulate the organ microenvironment and enable the growth of organ-specific tumor colonies, which can be used to investigate...
This $175,000 National Science Foundation project grant supports the development of multi-modal soft tissue characterization technologies for non-invasive breast imaging at the University of Massachusetts Dartmouth from April 2022 through March 2024. Funded under the NSF's Computer and Information Science and Engineering program (CFDA 47.070), the research aims to establish optimization algorithms and parameters for visualizing breast tissue cross-sections non-invasively using an integrated...
The National Science Foundation (NSF) Engineering program awarded a $377,755 Project Grant to the University of New Haven, Incorporated to support fundamental research on the mechanoregulation of collective cell migration in biomimetic microenvironments. This 3-year grant, effective from September 1, 2024 to August 31, 2027, will enable the University of New Haven to investigate how mechanical forces and biochemical factors interact to regulate collective cell migration, a crucial process in...
This National Science Foundation Project Grant of $606,649 will support the development of an engineered cyber-physical system combining advanced biological models and artificial intelligence methods to enable precision medicine for cancer treatment. Awarded under the Computer and Information Science and Engineering program, the funding will be used by Brigham and Women's Hospital and its parent organization Partners Healthcare System from October 2022 to September 2025. Specifically, the...
The National Science Foundation (NSF) awarded a $125,731 Project Grant to the Kennesaw State University Research And Service Foundation, Inc. (KSU R&SF) on October 1, 2023. The award is funded through the NSF's Engineering program (CFDA 47.041), which supports a wide range of research and development activities to advance engineering knowledge and capabilities. This particular award will tackle the challenge of exploring, analyzing, and interpreting the complex interactions in the tumor...