This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 provides funding to Clue Genetics Inc. for the development of a fungi-focused metabologenomics platform for natural product discovery. The key products and services to be delivered under this 1-year Phase I SBIR project include: Annotating biosynthetic gene clusters (BGCs) from 200 genomes selected from a diverse set of bioactive fungi to uncover new drugs,...
The U.S. National Science Foundation awarded a $275,000 SBIR Phase I Project Grant to Om Therapeutics Inc. in La Jolla, CA under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project aims to enable the discovery of new medicines at an unprecedented rate by empowering researchers to conduct drug discovery programs through the generation of massive, empirical, and scalable data on small molecule and protein interactions using machine learning. The key innovation is...
Biotech Naturale Inc. received a $256,000 Project Grant award from the National Science Foundation Division of Industrial Innovation under the Engineering federal grant program (CFDA 47.041) for the period of August 1, 2021 through July 31, 2022. The grant funds the development of a simple, targeted, and flexible method for transferring value-added genes from wild relatives of crop plants. The Engineering program seeks to improve quality of life and economic strength through fostering innovation...
This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...
Oakgrove Bio LLC was awarded a $256,000 Project Grant from the National Science Foundation Division of Industrial Innovation under the Engineering federal grant program (CFDA 47.041) for the period of December 1, 2021 to November 30, 2022. The grant funds the development of a cost-effective peptide production platform through SBIR Phase I funding. The Engineering program seeks to foster innovation and excellence in engineering research, and this award supports that goal by enabling Oakgrove...
Zymosense Inc. received a $256,000 Project Grant award from the National Science Foundation Division of Industrial Innovation on December 1, 2021 to develop a platform for rapid assessment of hydrolytic enzyme activity to optimize their design and use. The award is being carried out under the Engineering program (CFDA 47.041) of the NSF Directorate for Engineering, which seeks to improve quality of life and economic strength through engineering research and innovation. Under this one-year...
This $255,706 National Science Foundation SBIR Phase I Project Grant to Metfora LLC supports the development of a novel multiplexed metabolite diagnostic blood test for early detection of chronic diseases. The NSF Technology, Innovation, and Partnerships program aims to advance science and engineering solutions to national challenges through innovation and partnerships. Specifically, Metfora will use mass spectrometry and artificial intelligence to analyze specific panels of circulating...
This Project Grant award of $532,947 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is supporting the development and validation of a unified, cloud-based data processing workflow and database called LC-BINBASE for high-resolution LC-MS/MS metabolomics and lipidomics data. The project, led by a scientific team from UC Davis, the University of Michigan, and Pacific Northwest National Laboratory, aims to create a...
The National Science Foundation (NSF) has awarded a $1,000,000 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of Delaware. The objective of this 3-year grant, which runs from August 2024 to July 2027, is to develop a new strategy for real-time metabolite sensing and metabolon formation using biomolecular condensates. The research aims to create synthetic ligand-responsive transcription factor-based protein devices that can translate metabolite-induced DNA...
The National Science Foundation (NSF) Division of Chemistry has awarded a $303,509 Project Grant to Professor Young-Jin Lee and his team at Iowa State University to develop analytical technologies for advancing spatial metabolomics. Under this 3-year grant, the researchers will explore the use of on-tissue chemical derivatization (OTCD) coupled with mass spectrometry imaging (MSI) as a tool for untargeted spatial metabolomics. The key objectives are to: 1) develop bioinformatics tools to improve...