Project Grant 2334278

Award Date 5/1/24
Completion Date 4/30/25
Dollars Obligated $275K
Federal Grant Program
47.084
Assistance Type
Project Grant
Place of Performance
Hillsborough, NC 27278, USA
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This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Phase I Small Business Innovation Research (SBIR) grant for $275,000 aims to develop new bacterial strains capable of efficiently producing difficult-to-express proteins through precision fermentation. The project seeks to engineer improved bacterial hosts to manufacture proteins used in detergents, personal care products, and dairy, enabling the production of these products with lower environmental...
The National Science Foundation (NSF) awarded a $274,438 SBIR Phase I grant to Script Biosciences Inc. under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project, titled "CASPLUS: A Safer, More Efficient, and Targeted Method of Deploying CRISPR In Vivo," aims to develop a platform technology that significantly reduces the potential inaccuracy of current gene editing techniques. The innovation targets the desired gene, increasing the safety and efficacy...
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This Project Grant award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships program) provides $275,000 to Ubiquitx Inc., a New York-based small business, to develop a programmable, modular therapeutic platform for the direct modification of proteins of interest (POIs) using artificial intelligence, protein engineering, and mRNA therapeutics. The goal is to expand the applications of the company's Chimeric Ligands for Induced Proximity (CLIPS)...
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This $275,000 SBIR Phase I Project Grant, awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a generalized process to formulate and stabilize beneficial microbes for widespread adoption. The project, conducted by Seia Bio Inc., seeks to address the challenge of microbial stability when exposed to stressors such as heat, UV light, shock, and humidity. The proposed R&D will advance the understanding...
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This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 provides funding to Clue Genetics Inc. for the development of a fungi-focused metabologenomics platform for natural product discovery. The key products and services to be delivered under this 1-year Phase I SBIR project include:

  1. Annotating biosynthetic gene clusters (BGCs) from 200 genomes selected from a diverse set of bioactive fungi to uncover new drugs, insecticides, antibiotics, and novel enzymes.

  2. Designing at least 15 heterologous expression constructs encoding compounds such as verticillins, antimicrobials, and insecticidal agents for further development in a planned Phase 2 project.

  3. Identifying over 100 valuable enzyme candidates that can have immediate commercial applications.

The overall goal is to develop the foundational platform, tools, and resources needed to access the powerful chemistry found in fungi through modern synthetic biology and genomics approaches. This has the potential to address global challenges related to disease, pollution, and climate change.

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