Project Grant 2050255

The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded Vanderbilt University Medical Center a $300,000 Project Grant under the Engineering (47.041) federal grant program. The three-year award, issued on June 1, 2021 and concluding on May 31, 2024, will support collaborative research to understand the effects of flow on smooth muscle cells in an arteriole-sized microchannel. Specifically, VUMC will analyze flow conditions and interactions at the...

This Project Grant award from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041 - Engineering) supports a $320,155 research project at Purdue University to investigate the complex flow and transport processes within microvascular networks and their impact on vascular remodeling. The key objectives are to develop a novel computational model integrated with high-resolution imaging data to gain fundamental understanding...

Summary The University of North Carolina at Chapel Hill received a $618,352 Project Grant award dated July 15, 2026, from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct mechanistic research on endothelial dysfunction and cardiovascular disease. The grant funds a four-year research initiative (through March 31, 2031) investigating how mechanical forces—specifically oscillatory shear stress from disturbed blood flow...

Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1.45 million Project Grant to the University of California, Davis on August 5, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). The four-year award, concluding May 31, 2029, funds basic mechanistic research investigating direct pressure regulation of vascular L-type calcium channels (CAV1.2) in vascular smooth muscle and the underlying molecular pathways controlling the myogenic...

This $100,228 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded December 15, 2026, supports basic mechanistic research investigating the role of CCAAT/enhancer-binding protein beta (C/EBPβ) in flow-induced reprogramming of endothelial cells (FIRE) and atherosclerosis development. The research seeks to elucidate how disturbed blood flow triggers endothelial cell dysfunction, including inflammatory...

This $321,720 Project Grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) to The Pennsylvania State University will fund a 3-year experimental research study to characterize the transition to turbulent flow in pulsatile pipe flows. The project aims to provide fundamental understanding of the pulsatile transitional flow regime and develop tools for estimating intermittency and transition progression. Key focus areas include investigating the effects of axial...

Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $694,723 to the University of Nevada, Reno under the Cardiovascular Diseases Research program (CFDA 93.837) for a four-year project commencing September 1, 2025 and concluding June 30, 2029. The research project will investigate the regulation of capillary blood flow through thin-stranded pericytes, specialized perivascular cells located in the microvasculature. The research deliverables include...

The National Science Foundation (NSF) awarded a $400,000 Project Grant under the Engineering program (CFDA 47.041) to the New Jersey Institute of Technology (NJIT) to advance the understanding of how new blood vessels grow in the body. This 3-year project aims to develop data-driven models that integrate high-fidelity biophysical simulation with high-resolution imaging of real blood vessel networks undergoing growth and adaptation. The research will elucidate the fluid dynamics and biophysics...

This two-year, $400,138 project grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems will fund research into instabilities in suspension flows. The University of Illinois will conduct laboratory experiments and apply existing theory to explore suspension flows in structured channels. Researchers will characterize the laminar steady state as a function of Reynolds number for specified particle sizes and volume fractions. They will...

The National Science Foundation (NSF) awarded a 5-year, $539,532 CAREER (Faculty Early Career Development) grant to the University of Illinois to research predictive multiscale modeling of cell migration through pores between endothelial cells. The project will study the biomechanics and mechanobiology of transendothelial migration for three cell types: red blood cells, neutrophils, and tumor cells. Advanced computer simulations will be used to predict how different cell components affect the...