The U.S. Department of Agriculture (USDA) awarded a $650,000 Project Grant under the Agriculture and Food Research Initiative (CFDA 10.310) to Oklahoma State University (OSU) to conduct research on developing an antibiotic-free approach to combat necrotic enteritis (NE) in poultry. Specifically, the project will screen additional commensal bacteria for their ability to inhibit the growth of Clostridium perfringens, the bacterium that causes NE, and induce host defense peptide synthesis to enhance innate immunity. Lead bacterial candidates will be further evaluated for their protective efficacy in NE-infected chickens, and the mechanism of action for the most effective bacterium will be studied. Upon completion by June 30, 2027, the project aims to identify several commensal bacteria that can effectively mitigate NE and reveal their major mechanism of action, facilitating the development of an innovative antibiotic-free solution to address this economically devastating poultry disease.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $650.0k | 5/10/24 |