This $650,000 Project Grant awarded by the USDA National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) CFDA 10.310 program aims to evaluate the safety and efficacy of a genetically engineered Bacillus subtilis probiotic strain in reducing Salmonella colonization in broiler chickens. The primary awardee, the Regents of the University of Michigan, will develop a B. subtilis strain that secretes Salmonella-neutralizing nanobodies to directly inhibit pathogen growth and proliferation in poultry. The project will assess the in vivo safety and pharmacokinetics of this engineered probiotic in broilers, as well as its efficacy in decreasing Salmonella loads (Years 1-3). The University of Georgia Research Foundation was awarded a $320,000 sub-grant to conduct complementary studies on the anti-Salmonella effects and histology of the B. subtilis intervention in broiler birds. This platform technology aims to provide a new approach for controlling Salmonella in poultry and ultimately expand to target other enteric pathogens, improving animal welfare and food safety.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $650.0k | 5/16/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
SUBK00020320S | University Of Georgia Research Foundation, Inc. | Project Grant 20246701542413 | $300.0k | 6/27/24 |