Penn State University received a $650,000 Project Grant award from the United States Department of Agriculture National Institute of Food and Agriculture under the Agriculture and Food Research Initiative (AFRI) federal grant program. The grant will fund research from May 1, 2023 to April 30, 2027 to test the hypothesis that overactivation of the androgen membrane receptor ZIP9 in cattle ovarian cells will lead to ovarian fibrosis, altered gene expression and impaired ovarian function. The university will utilize in vitro culture of ovarian cells, intact follicles and ovarian explants to study the consequences of excessive androgen stimulation on ovarian function. The research aims to further understanding of how high androgen levels cause conditions like follicular cysts, anovulation and reduced fertility in cattle and other mammalian species. Results have the potential to inform methods to mitigate these effects and improve reproductive efficiency in cattle.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $650.0k | 4/24/23 |