Project Grant 20246701542451
- The Department of Agriculture's National Institute of Food and Agriculture awarded a $120,000 Project Grant under the Agriculture and Food Research Initiative competitive grants program to Virginia Polytechnic Institute & State University from July 2021 through June 2023. The grant funds research to investigate embryonic losses occurring during blastocyst hatching and embryo elongation in cattle, which can significantly impact the cattle industry. The principal investigator will...
- Federal Grant Award Summary Texas A&M AgriLife Research received a $650,000 project grant from the U.S. Department of Agriculture's National Institute of Food and Agriculture under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310), awarded February 1, 2026, with a completion date of January 31, 2029. The grant supports foundational research investigating the physiological and molecular mechanisms contributing to embryonic mortality in cattle, a primary driver of...
- This $500,000 project grant from the United States Department of Agriculture National Institute of Food and Agriculture (USDA NIFA) supports research under the Agriculture and Food Research Initiative competitive federal grants program (AFRI; CFDA #10.310). The Virginia Polytechnic Institute and State University will characterize differences in early embryonic development and uterine environments between cattle breeds that are more resilient to undernutrition and less prone to pregnancy loss,...
- Federal Grant Award Summary Texas A&M AgriLife Research received an $800,000 project grant from the USDA's Agriculture and Food Research Initiative (AFRI) (CFDA 10.310), awarded September 1, 2025, with completion targeted for August 31, 2028. The project delivers a comprehensive population-scale atlas of bovine enhancer variation and its effects on gene expression, addressing a critical gap in the Functional Annotation of Animal Genomes (FAANG) initiative. The research applies CAGE-seq...
- This $650,000 Project Grant from the National Institute of Food and Agriculture, part of the U.S. Department of Agriculture, will fund research under the Agriculture and Food Research Initiative competitive grants program. The awardee, the Agricultural Research Service located in Fort Collins, Colorado, will develop techniques using strategically-coated magnetic nano-particles to remove defective spermatozoa from bull semen. Field studies will then evaluate the reproductive potential of the...
- Federal Grant Award Summary Cornell University's Office of Sponsored Programs received a $300,000 project grant from the Institute of Food Production and Sustainability under the Agriculture and Food Research Initiative (AFRI, CFDA 10.310) awarded March 1, 2026, with completion scheduled for February 29, 2028. The grant supports fundamental research addressing early embryonic loss in cattle, a significant constraint on reproductive efficiency in U.S. beef and dairy operations. The project...
- Federal Grant Award Summary Washington State University received a $300,000 Project Grant award from the National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI, CFDA 10.310) program, with performance scheduled from February 1, 2026, through January 31, 2028. The project investigates epigenetic modifications in cattle placental development to improve pregnancy establishment and reduce pregnancy loss in dairy heifers. The research will identify...
- Federal Project Grant Award Summary Texas A&M Agrilife Research received a $225,000 project grant from the U.S. Department of Agriculture's National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) (CFDA 10.310), effective July 1, 2025, through June 30, 2027. The award funds research addressing pregnancy failure in cattle, which affects approximately 50% of cattle within the first month of pregnancy and represents a significant economic...
- The Pennsylvania State University received a $120,000 project grant award from the United States Department of Agriculture National Institute of Food and Agriculture under the Agriculture and Food Research Initiative competitive grants program. The grant will fund research into the role of the PRAMEY protein in early bovine embryonic development and its potential influence on epigenetic remodeling. Penn State researchers will utilize in vitro fertilization techniques to produce cattle embryos at...
- Grant Award Summary The University of Wyoming received a $300,000 project grant from the U.S. Department of Agriculture's National Institute of Food and Agriculture under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310). The award, effective February 1, 2026 through January 31, 2028, funds research focused on understanding the functional role of Progesterone Receptor Membrane Component 1 (PGRMC1) in cattle pregnancy establishment and early fetal development. The research...
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** WHILE THE CURRENT CATTLE FAANG PROJECT EXCELS IN COMPREHENSIVELY UNDERSTANDING GENOMIC REGULATORY ELEMENTS IN A WIDE-RANGING SET OF ADULT AND FETAL CATTLE TISSUES, THERE IS A SIGNIFICANT KNOWLEDGE GAP REGARDING THE REGULATORY DYNAMICS OF DEVELOPMENT AND DIFFERENTIATION ACROSS THE CATTLE LIFECYCLE IN EACH TISSUE, WHICH DETERMINES ECONOMIC TRAITS IN ANIMAL HEALTH AND PRODUCTION. THIS STUDY AIMS TO FILL THIS GAP, FOCUSING ON MALE REPRODUCTION, WHICH IS IMPERATIVE AS THE CATTLE INDUSTRY RELIES ON ARTIFICIAL INSEMINATION (AI) PRACTICES. THE PROJECT COMPRISES THREE SPECIFIC AIMS: 1) DETERMINE THE TEMPORAL TRANSCRIPTOME DYNAMICS AND GENE REGULATORY NETWORKS DURING BOVINE TESTIS DEVELOPMENT, 2) DETERMINE GERM CELL-SPECIFIC TRANSCRIPTOME DYNAMICS AND GENE REGULATORY NETWORKS IN DIFFERENT GERM CELLS DURING SPERMATOGENESIS, AND 3) DETERMINE THE TESTIS-BIASED GENES AND IDENTIFY E/SQTL, AS WELL AS TRANSCRIPTOME-WIDE ASSOCIATION STUDIES (TWAS) OF MALE FERTILITY TRAITS. TO ACHIEVE THESE AIMS, WE WILL ANNOTATE AND INTEGRATE TRANSCRIPTIONAL PROFILES AND CHROMATIN STATES AT A WHOLE-GENOME LEVEL ACROSS THE FOUR DEVELOPMENTAL STAGES OF TESTES AND FIVE DIFFERENT TYPES OF GERM CELLS DURING SPERMATOGENESIS. ADDITIONALLY, SINGLE-CELL TRANSCRIPTOMICS AND CHROMATIN STATES WILL PROVIDE INSIGHTS INTO THE REGULATORY DYNAMICS OF BOVINE GERM CELL DIFFERENTIATION EVENTS. LASTLY, WE WILL IDENTIFY BULL FERTILITY-ASSOCIATED GENOMIC VARIANTS WITHIN THE ANNOTATED REGULATORY ELEMENTS IN THE TESTIS. TWAS WITH EVARIANTS AND COLOCALIZATION OF EQTLS AND GWAS LOCI WILL ENHANCE OUR ABILITY TO DETECT CANDIDATE CAUSAL GENES FOR MALE FERTILITY TRAITS. THIS PROJECT IS HIGHLY INNOVATIVE, CRUCIAL, AND SIGNIFICANT FOR COMPLETING THE BOVINE GENOME ANNOTATION AND UNDERSTANDING THE TRANSCRIPTOMICS UNDERLYING TESTIS DEVELOPMENT AND SPERMATOGENESIS IN RUMINANTS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $650.0k | 5/21/24 |