Institutional clinical and translational science award

The National Center for Advancing Translational Sciences awarded a $10.805 million Cooperative Agreement to the University of Pennsylvania on July 1, 2026, under the National Center for Advancing Translational Sciences program (CFDA 93.350).

The Penn-CHOP Clinical and Translational Science Award (CTSA) Hub will advance clinical and translational science through four integrated aims: developing and disseminating novel approaches to translational therapeutics; applying data science resources and dynamic data ecosystems to establish a Penn-CHOP academic learning health system framework; integrating the hub with communities and stakeholders to promote community-partnered and collaborative research across the lifespan; and educating, training, and retaining a multidisciplinary workforce in clinical and translational research. The hub will serve as a national model for integrated, community-engaged, data-driven translational science, leveraging the institution's strengths in translational therapeutics, data science, community engagement, and workforce development to accelerate delivery of innovative therapies and contribute to the CTSA Consortium's collective impact on public health.

Performance occurs in Philadelphia, Pennsylvania. The period of performance extends from July 1, 2026, through May 31, 2033.

Abstract

The penn-chop clinical and translational science award (ctsa) hub proposes a transformative vision to catalyze a dynamic clinical and translational science (CTS) ecosystem that accelerates the delivery of innovative, life-altering therapies to individuals across the lifespan. Aligned with the ncats mission to bring more treatments to all people more quickly, our hub will leverage its nationally-recognized strengths in translational therapeutics, data science, community engagement, and workforce development to advance the science and practice of clinical translation. We propose four integrated aims: (1) innovate novel approaches to advancing the development and dissemination of translational therapeutics; (2) accelerate the application of state-of-the-art data science resources and dynamic data ecosystems to enable a penn-chop academic learning health system (alhs) framework and catalyze groundbreaking CTS; (3) integrate our hub with our communities and stakeholders to promote community-partnered and collaborative research within families and across the lifespan; (4) educate, train, advance, and retain a skilled multidisciplinary workforce ready to meet the demand of an ever-evolving CTS and and CTR landscape. Our hub will serve as a national model for integrated, community-engaged, and data-driven translational science. Through rigorous evaluation, continuous quality improvement, and dissemination of best practices, we aim to contribute meaningfully to the ctsa consortium's collective impact on public health.