The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $639,084 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program to Childrens Hospital Medical Center in Cincinnati, Ohio. The grant, awarded on March 19, 2025, supports a research project titled "NAIVE CD8 T CELL FUNCTIONAL HETEROGENEITY" that aims to elucidate the heterogeneity of naive CD8 T cells and understand how this impacts immune responses and T cell...
This Cooperative Agreement award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Grant Program (CFDA 93.855), supports research to enhance understanding of the phenotypes, endotypes, and mechanisms of immediate-onset allergic reactions to antibiotics. The total funding amount is $427,671, with the project period running from July 3, 2025 to June 30, 2027. The awardee, The General Hospital Corporation doing business...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $395,496 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, San Francisco. The grant supports a study using metagenomic next-generation sequencing (MNGS) to provide novel insights into pathogen transmission and antimicrobial resistance acquisition in neonatal intensive care units (NICUs). The research aims to: 1) identify nosocomial transmission...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $689,068 Project Grant under CFDA 93.855 Allergy and Infectious Diseases Research to the University of Cincinnati to establish ex vivo growth systems for the fungal genus Pneumocystis. The key objectives are to: 1) conduct metabolite profiling and flux balance analysis to identify critical nutrients for growth of the P. carinii surrogate in a cell-free culture system, and 2) develop rat and human alveolar organoids to...
This $2,654,646 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports a multi-year program to better understand the unique characteristics of the human immune response in early life. The program aims to uncover genetic and developmental determinants of pediatric immunity, examine how immune parameters evolve over childhood, and elucidate how baseline immune states predict responses to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $894,735 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to St. Jude Children's Research Hospital Inc. The grant will fund the development of a novel positron emission tomography (PET) imaging agent, [18F]fluoromannitol, to diagnose and monitor bacterial osteomyelitis in patients with sickle cell disease. Key objectives include establishing a streamlined radiosynthesis, validating...
This $797,735 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to elucidate the cellular and molecular mechanisms governing heightened immune responses in neonates. The research project will utilize a novel mouse model to investigate how the innate immune system detects and mediates sterile inflammation during early life development, with the goal of developing targeted...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $286,791 to Childrens Hospital Medical Center in Cincinnati, Ohio to develop and apply pediatric-specific blood transcriptional modules (PBTMs) across diverse geographical settings through public data mining. The project aims to construct robust and widely applicable PBTMs that capture the broad range...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $126,174 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to the University of California, Davis (UC Davis). The grant, with a performance period from May 29, 2025 to Dec 31, 2027, will support research to investigate the local immune response in bacterial skin infections using a novel skin-on-a-chip model. Specifically, the project aims to demonstrate the role of...
This Cooperative Agreement award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $443,527 to Brigham & Women's Hospital, Inc. to conduct translational research to advance the understanding and clinical care of antibiotic-induced delayed-type drug hypersensitivity reactions. The project aims to investigate potential "X-factors" that may critically drive the onset, phenotype,...