Maximizing outcomes of repeat trichiasis surgery performed by integrated eye care workers
Active Cooperative Agreement Awarded Last action
- Award ID
- UG1EY036891
- Recipient
-
University Of North Carolina At Chapel Hill UEI D3LHU66KBLD5 Part of University Of North Carolina System Office
- Awarding agency
-
National Eye Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $10,991,304
Award facts
- Assistance listing
- 93.867 Vision Research
- Completion date 30% complete
- Place of performance
- Chapel Hill, NC 27599, USA
Award details come from USAspending.gov.
Description
- Abstract
- Trachoma is the leading infectious cause of blindness globally, and IT disproportionally affects the world's most marginalized populations. Trachomatous trichiasis (TT) is a condition resulting from years of repeated ocular chlamydia trachomatous infections that cause the eyelid to turn in and the eyelashes to RUB the eye, eventually leading to blindness. While surgery is available to correct trichiasis, more than 20% of patients experience post-operative trichiasis (PTT) needing further surgical management. Yet, current management procedures for post-operative trichiasis are suboptimal. A recently completed clinical trial, besrat, compared an existing surgery procedure (posterior lamellar tarsal rotation) against a newly developed procedure, bevel-rotate advancement procedure (b-RAP). The trial used the best surgeons available. The trial suggested that b-RAP performed better than the existing procedure, particularly for patients with severe PTT or an eyelid contour abnormality at the time of repeat surgery. The next step is to determine whether a larger group of TT surgeons can perform b-RAP well and to compare IT against the other standard TT surgery procedure, bilamellar tarsal rotation (bltr). The primary objective of this randomized clinical trial is to determine whether repeat trichiasis surgery performed with b-RAP improves surgical success compared to bltr among a group of 8-10 district TT surgeons in tanzania. The study aims to enroll 1,000 individuals with PTT. The primary outcome is repeat PTT within one year after surgery. Additionally, the study will assess eyelid contour abnormalities and how they change over a two-year period as well as patient reported outcomes. If this project is successful in improving surgical outcomes, IT could change the approach to treating PTT globally. Individuals with trichiasis have a significantly reduced quality of life; correcting their trichiasis long-term has the potential to improve their quality of life and their family members' quality of life considerably.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $575,986 | |
| Amendment | $933,644 | |
| Amendment | $933,644 | |
| Amendment | -$698,817 | |
| Amendment | $698,817 | |
| Amendment | -$698,817 | |
| Amendment | $698,817 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $1,709,606 | |
| Amendment | $1,709,606 | |
| Amendment | $1,709,606 | |
| Amendment | $1,709,606 | |
| Original award | $1,709,606 |
Show all 19
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Kongwa Trachoma Project | $1,274,803 | |
| Rector & Visitors Of The University Of Virginia | $168,953 | |
| The Trustees Of The University Of Pennsylvania | $144,994 |
Quick answers
Who received award UG1EY036891?
UG1EY036891 was awarded to University Of North Carolina At Chapel Hill by National Eye Institute (National Institutes of Health) on May 1, 2025.
How much is award UG1EY036891 worth?
$10,991,304 has been obligated on UG1EY036891.
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