Cooperative Agreement UC2AR086503
- This $2,319,459 Cooperative Agreement award was granted by the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), to Seattle Children's Hospital (doing business as Seattle Children's Research Institute) to develop a precision health model for pediatric chronic primary pain. The key objectives are to leverage the electronic health record data from the PEDSnet national pediatric learning health system to: 1) develop...
- This $4,649,740.00 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund a study to understand inter-individual differences in the clinical trajectory of chronic musculoskeletal pain (CMSKP). The research aims to develop network representations of patients' lived experience of pain and functional state using language models and home-based videos, and to analyze state transitions in...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $9,237,770 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Washington University to conduct the "IMPETUS: Integrated Mechanisms, Phenotypes, and Translational Underpinnings of Chronic Pain After Surgery" research project. The goal is to gain integrated mechanistic insights into peripheral and central biological processes that contribute to chronic postsurgical pain...
- This federal Project Grant award for $5,057,591.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports a 4-year prospective observational study at The Ohio State University to comprehensively characterize pain phenotypes, optimal pain treatment strategies, and predictive models of pain trajectories in emergency department (ED)...
- This federal Project Grant award of $1,764,145.00 from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop effective pharmacological interventions to alleviate chronic pain in sickle cell disease (SCD). The award supports research to investigate the functional role of microRNA (miRNA), specifically the let-7 family, in regulating chronic pain pathways in SCD. The project will utilize mouse models...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $147,486 Project Grant to Carnegie Mellon University under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The grant supports research to identify and target neural subpopulations in the spinal cord that mediate chronic pain, with the goal of developing more effective and targeted treatments. The research will analyze cell-type-specific cis-regulatory elements (CREs) in...
- This federal Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,425,183 to support a SMART (Sequential, Multiple Assignment, Randomized Trial) design study at the University of Michigan Back Pain Consortium (BACPAC) Mechanistic Research Center. The study aims to evaluate personalized multicomponent therapies for chronic low back pain, including pharmacological,...
- This Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), is funded under the Drug Use and Addiction Research Programs (CFDA 93.279). The $1,570,904 award to the University of Pittsburgh aims to deepen the understanding of the key features associated with the overall experience of chronic low back pain (CLBP) in order to promote whole-person health. The project leverages the successful...
- This federal Project Grant award of $129,113 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the SPARQ: Summer Program to Advance Research and Equity in Pain and Neurological Health at Seattle Children's Hospital. The 9-week program aims to expose 10 undergraduate students per year to rigorous, interdisciplinary pain and neuroscience research, with a...
- This $664,772 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate a novel, non-opioid spinal analgesic mechanism for the treatment of high impact chronic pain. The primary awardee, the University of Texas Southwestern Medical Center, will evaluate the signaling pathway involving the neurotensin receptor 2 (NTSR2) and...
This $1,955,201.00 Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS) supports a research project titled "Biopsychosocial Determinants of Pediatric-Onset Chronic Musculoskeletal Pain" under the Drug Use and Addiction Research Programs (CFDA 93.279). The project aims to enroll 600 adolescents and young adults, including 400 with chronic musculoskeletal pain and 200 without, to study the underlying biopsychosocial mechanisms driving pediatric-onset chronic pain conditions. The research will leverage existing patient registries and cohorts at Cincinnati Children's Hospital Medical Center to collect retrospective and prospective data on pain characteristics, sensory testing, and other biomarkers. The goal is to develop a more mechanistic understanding of pediatric chronic pain in order to inform the development of novel treatment strategies. The award period runs from September 19, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.0m | 9/19/25 |