Cooperative Agreement U01HG007599

Federal Grant Award Summary The Broad Institute of MIT and Harvard received a $315,060 Project Grant from the National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), awarded June 10, 2025, with completion targeted for May 31, 2026. The grant supports the development of a cell-type-specific atlas of transcription factor (TF)-element connectivity across human tissues by integrating single-cell and single-nucleus Assay for...

This Cooperative Agreement award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) will provide $1,418,806 to the University of Washington to develop transformative tooling for accurately incorporating epigenetic data into a human pan-genome reference. The key products and services to be delivered include: Developing machine learning models to classify long-read epigenetic data from diverse experimental and sequencing methods. Aggregating long-read...

This two-year project grant from the National Science Foundation's Computer and Information Science and Engineering program aims to develop deep learning methods for high-resolution three-dimensional genome structure spatial reconstruction. With a total funding amount of $175,000, the award was issued on May 1, 2022 to the University of Colorado Colorado Springs to complete the project by April 30, 2024. The grantee will apply sophisticated and automated deep learning approaches to infer...

Federal Cooperative Agreement Summary The University of Chicago received a $716,623 Cooperative Agreement award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), effective September 1, 2025 through August 31, 2030. The award funds the creation of a multi-tissue DNA methylation (DNAm) data resource designed to advance understanding of epigenetic variation across diverse human tissue types. The primary product is a comprehensive...

Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), awarded a Project Grant of $721,450 to The Leland Stanford Junior University, effective March 1, 2026 through February 28, 2030. This award supports research to develop genome-wide maps of enhancer-gene regulatory interactions that will enable researchers to link noncoding genetic variants to their functional consequences in human disease. The project...

The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $384,418 Project Grant to Xgenomes Corp. on September 25, 2024 to develop a revolutionary DNA sequencing platform. The project aims to create a super-resolution single-molecule sequencing technology that can read short sequence "words" rather than individual nucleotides, enabling one or more orders of magnitude improvements in accuracy and cost over...

Federal Project Grant Award Summary Xgenomes Corp. received a $795,198 Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded June 1, 2025, with a completion date of February 28, 2027. The grant funds development of a novel epigenetic analysis method for sequencing DNA methylation modifications across the genome using single-molecule detection of oligonucleotide binding kinetics. This technology addresses critical...

This $225,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will fund research into the detailed characterization of topologically associating domain (TAD) boundaries in eukaryotic genomes. The grant supports the Biological Sciences program, which aims to increase scientific knowledge of major biological problems. The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, will...

This Cooperative Agreement award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $784,000 to the New York Genome Center, Inc. (Nygc) to develop statistical methods and analytical approaches for extracting insights into human and non-human primate tissue development and disease from the Developmental GTEx (dGTEx) project's multi-modal, multi-tissue data....

The National Human Genome Research Institute (NHGRI) awarded a $457,920 Project Grant (CFDA #93.172 - Human Genome Research) to The Broad Institute, Inc. to develop a deep reinforcement learning framework for haplotype assembly. Haplotype assembly is critical for understanding human population genetics and disease, as it reconstructs the combination of alleles on maternally and paternally inherited chromosome copies. The Broad Institute, a renowned biomedical and genomic research organization,...