This federal Cooperative Agreement award from the Food and Drug Administration (FDA) Research program (CFDA 93.103) provides $1,277,294 to the University of Wisconsin System to enroll 180 individuals with the CADASIL gene mutation in a study investigating retinal imaging measures as potential diagnostic, prognostic, and disease monitoring biomarkers for vascular cognitive impairment and dementia. The study, which began on September 5, 2024, will focus on three primary retinal assessments: 1) retinal capillary bed pathology, 2) retinal arteriolar changes, and 3) inner plexiform layer thickness. The project aims to determine the strength of these retinal imaging biomarkers for use in clinical trials for neurodegenerative diseases with cerebrovasculopathies. Georgia State University Research Foundation Inc. and the University of Rhode Island are sub-awardees, responsible for conducting retinal imaging assessments and data analysis at their respective sites.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 9/23/24 | ||
| Not listed | $0 | 9/7/24 | ||
| Not listed | $1.3m | 9/4/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
0000004152S | Georgia State University Research Foundation Inc. | Cooperative Agreement U01FD008399 | $181.0k | 2/5/25 | |
0000004145S | University Of Rhode Island | Cooperative Agreement U01FD008399 | $93.6k | 1/23/25 |