Driving next generation UPR inhibitory kinase inhibitors for T1D
Active Cooperative Agreement Awarded Last action
- Award ID
- U01DK143500
- Recipient
-
The Regents Of The University Of California. San Francisco UEI KMH5K9V7S518
- Awarding agency
-
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $3,194,538
Award facts
- Assistance listing
- 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research
- Completion date 32% complete
- Place of performance
- San Francisco, CA 94143, USA
Award details come from USAspending.gov.
Description
- Abstract
- Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by hyperglycemia due to progressive immune-mediated destruction of pancreatic beta cells. Recent work from our laboratories has shown that hyperactivation of the unfolded protein response (UPR) to ER stress in the immune-targeted beta cells may be a critical early event in the development of T1D. We have developed novel pharmacological reagents called 'pair's that allow US to manipulate components of the UPR. Importantly, first-generation versions of small molecules delivered to NOD mice can efficaciously prevent and even reverse diabetes in this T1D model. Thus, in this collaborative grant we will capitalize on the complementary expertise of the investigators to optimize these next-generation "pair" molecules for potency and selectivity, conduct proof-of-concept studies using human islets (EX vivo and in transplanted mice), and perform key enabling steps needed to advance these candidates further into the clinic for treating human patients with T1D.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $2,378,213 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Original award | $816,325 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| University Of Washington | $209,925 |
Quick answers
Who received award U01DK143500?
U01DK143500 was awarded to The Regents Of The University Of California. San Francisco by National Institute of Diabetes and Digestive and Kidney Diseases (National Institutes of Health) on August 1, 2025.
How much is award U01DK143500 worth?
$3,194,538 has been obligated on U01DK143500.
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