This $2,811,343 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports the Center for Genetics, Genomics, and Epigenetics of Substance Use Disorders in Outbred Rats. The primary goals are to provide critical core services to a community of researchers using outbred heterogeneous stock (HS) rats to study the genetic basis of individual differences in vulnerability to substance use disorders. Key services...
This federal Cooperative Agreement award of $2,094,403.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to identify genes that affect behaviors associated with substance use disorders (SUDs). The University of California, Los Angeles (UCLA) will conduct a novel mechanism-to-gene strategy to genetically map circuit-driven behavioral outputs related to anxiety and SUDs. The key research activities...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support a $346,911 cross-species research study to identify early life environmental and genetic risk factors for substance use disorders (SUDs). The key objectives are to: 1) determine how early life environment influences neurocognitive development and its relationship to adult impulsivity behaviors; 2) identify genomic networks associated...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a multivariate genome-wide association analysis of opioid-related traits in a diverse population of over 500,000 individuals. The $715,238 award, effective January 15, 2025 through November 30, 2029, will enable researchers at the University of California, San Diego to investigate the genetic basis of pre-addiction opioid use stages,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to develop a translational rat model of the neonatal intensive care unit (NICU) experience and its impacts on substance use disorder risk. The $368,315 award to the Georgia State University Research Foundation will: 1) design and test a model combining early pain, resource scarcity, and separation from caregivers to mimic key aspects of...
This $284,040 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to conduct integrated single-cell and spatial mapping of the habenula circuitry to identify projection-specific molecular pathways associated with opioid exposure. The Lieber Institute for Brain Development in Baltimore, MD will lead this research effort from September 1, 2024 to August 31, 2026. The project will generate a...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $357,613 to Yale University to conduct research aimed at improving the understanding of the genetic mechanisms underlying substance use disorders (SUDs). The key objectives of this 2-year project are to: 1) leverage large-scale whole-genome sequencing (WGS) datasets to identify novel rare and common genetic variants associated with SUDs and recover...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to study the neurogenetic mechanisms underlying nicotine and cannabis addiction. The $175,888 award, effective September 1, 2024 through August 31, 2028, will enable the development of novel transcriptome-connectome analysis methods to identify genes associated with changes in brain functional connectivity related to addiction. The...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support research to explore the unique neurobehavioral profile of sequential opioid-stimulant polysubstance use disorders. The $314,225 award, effective July 31, 2024 through February 28, 2025, will fund a study conducted by the University of Washington to: 1) Define the behavioral profile of dual opioid-methamphetamine use disorders in a...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $445,500.00 to the University of Alabama at Birmingham (UAB) to conduct high-throughput identification and characterization of conserved regulators of drug-induced plasticity in the Caenorhabditis elegans nervous system. The goal is to generate comprehensive molecular, behavioral, and neuronal activity atlases in response to acute and...